Patient derived xenograft

Patient derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse.[1] It is a form of xenotransplantation. PDX models are used to create an environment that allows for the continued growth of cancer after its removal from a patient. In this way, tumor growth can be monitored in the laboratory, including in response to potential therapeutic options.[1] Cohorts of PDX models can be used to determine the therapeutic efficiency of a therapy against particular types of cancer, or a PDX model from a specific patient can be tested against a range of therapies in a 'personalized oncology' approach.[2]

  1. ^ a b Cite error: The named reference lai was invoked but never defined (see the help page).
  2. ^ Ahmed A, Cox E, Lane L, Rominiyi O, Danson S, Bryant HE, et al. (2025-03-10). "Ex Vivo Drug Screening: An Emerging Paradigm in the Treatment of Childhood Cancer". Journal of Pediatric Hematology/Oncology. doi:10.1097/MPH.0000000000003017. ISSN 1077-4114.
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