Perindopril
Above: molecular structure of perindopril
Below: 3D representation of a perindopril molecule | |
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| Trade names | Coversyl, Coversum, Aceon |
| AHFS/Drugs.com | Perindopril Monograph[1] |
| MedlinePlus | Perindopril |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | 24% |
| Protein binding | 20% |
| Metabolism | Kidney |
| Elimination half-life | 1–17 hours for perindoprilat (active metabolite) |
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| ECHA InfoCard | 100.120.843 |
| Chemical and physical data | |
| Formula | C19H32N2O5 |
| Molar mass | 368.474 g·mol−1 |
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Perindopril is a medication used to treat high blood pressure, heart failure, or stable coronary artery disease.[3][4][5]
As a long-acting ACE inhibitor, perindopril works by inhibiting production of the vasoconstriction hormone, angiotensin, thereby relaxing blood vessels, increasing urine output, and decreasing blood volume, leading to a reduction of blood pressure. It also increases blood renin activity and decreases aldosterone secretion, causing increased urine production and excretion of sodium.[3]
As a prodrug, perindopril is hydrolyzed in the liver to its active metabolite, perindoprilat. It was patented in 1980 and approved for medical use in 1988.[3][6]
Perindopril is taken in the form of perindopril arginine/amlodipine or perindopril erbumine.[1] Both forms are therapeutically equivalent and interchangeable,[1][3] but the dose prescribed to achieve the same effect may differ between the two forms.[1]
Perindopril should not be used during pregnancy, as it may harm the fetus.[1] Some people may have allergic reactions to perindopril, while common side-effects may include cough, headache, dizziness, diarrhea, or upset stomach.[1]
In Australia during 2023-24, it was the fourth-most prescribed drug.[7]
- ^ a b c d e f "Perindopril". Drugs.com. 24 February 2025. Retrieved 28 March 2025.
- ^ "Regulatory Decision Summary for APO-Perindopril Arginine". Health Canada. 23 October 2014.
- ^ a b c d "Perindopril erbumine tablet". DailyMed, US National Library of Medicine. 13 March 2024. Retrieved 28 March 2025.
- ^ "Perindopril". MedlinePlus, US National Library of Medicine, US National Institutes of Health. 20 July 2024. Retrieved 28 March 2025.
- ^ "Consumer Medicine Information, GenRx Perindopril" (PDF). Clinical Resources, Medicine information for health professionals. Royal Australian College of General Practitioners. Archived from the original (PDF) on 1 September 2007.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 467. ISBN 9783527607495.
- ^ "Top 10 drugs 2023-24 (Australia)". Australian Prescriber. 47 (6): 194. December 2024. doi:10.18773/austprescr.2024.048. PMC 11703566. PMID 39777038.