Pholedrine

Pholedrine
Clinical data
Trade names	Paredrinol, Presoitan, Pulsotyl, Veritain, Veritol
Other names	4-Hydroxy-N-methylamphetamine; 4-HMA; 4-Hydroxymethamphetamine; para-Hydroxymethamphetamine; PHMA; Hydroxymethamphetamine
Routes of; administration	Topical (ocular)
Identifiers
	IUPAC name 4-[2-(Methylamino)propyl]phenol;
CAS Number	370-14-9 ;
PubChem CID	4655;
DrugBank	DBMET00735;
ChemSpider	4494 ;
UNII	AY28O44JGD;
KEGG	D08370 ;
ChEBI	CHEBI:134798;
ChEMBL	ChEMBL2008672;
CompTox Dashboard (EPA)	DTXSID70861908 ;
ECHA InfoCard	100.006.114
Chemical and physical data
Formula	C10H15NO
Molar mass	165.236 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc(cc1)CC(NC)C;
	InChI InChI=1S/C10H15NO/c1-8(11-2)7-9-3-5-10(12)6-4-9/h3-6,8,11-12H,7H2,1-2H3 ; Key:SBUQZKJEOOQSBV-UHFFFAOYSA-N ;
	(verify)

Pholedrine, also known as 4-hydroxy-N-methylamphetamine and sold under the brand names Paredrinol, Pulsotyl, and Veritol among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil.^[1]^[2]^[3] It can be used to diagnose Horner's syndrome.^[3]

In 2004, it remained marketed only in Germany.^[1]

^ ^a ^b Schweizerischer Apotheker-Verein (2004). Index Nominum: International Drug Directory. Medpharm Scientific Publishers. p. 969. ISBN 978-3-88763-101-7. Retrieved 30 August 2024.
^ "Pholedrine". National Library of Medicine. Retrieved 24 June 2023.
^ ^a ^b Bates AT, Chamberlain S, Champion M, Foley L, Hughes E, Jani B, et al. (February 1995). "Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome". Journal of Neurology, Neurosurgery, and Psychiatry. 58 (2): 215–217. doi:10.1136/jnnp.58.2.215. PMC 1073320. PMID 7876854.