Pralidoxime

Pralidoxime
Clinical data
Other names	1-methylpyridine-6-carbaldehyde oxime
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	C;
ATC code	V03AB04 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 2-[(hydroxyimino)methyl]-1-methylpyridin-1-ium;
CAS Number	6735-59-7 ;
PubChem CID	6789253;
IUPHAR/BPS	4652;
DrugBank	DB00733 ;
ChemSpider	5193737 ;
UNII	P7MU9UTP52;
KEGG	C07400 ;
ChEBI	CHEBI:8354 ;
ChEMBL	ChEMBL1420 ;
CompTox Dashboard (EPA)	DTXSID1044144 ;
ECHA InfoCard	100.027.080
Chemical and physical data
Formula	C7H9N2O+
Molar mass	137.162 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ON=Cc1cccc[n+]1C;
	InChI InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1 ; Key:JBKPUQTUERUYQE-UHFFFAOYSA-O ;
	(verify)

Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase.^[1] It is used to treat organophosphate poisoning^[2] in conjunction with atropine and either diazepam or midazolam. It is a white solid.

^ Jokanović M, Stojiljković MP (December 2006). "Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning". European Journal of Pharmacology. 553 (1–3): 10–7. doi:10.1016/j.ejphar.2006.09.054. PMID 17109842.
^ Jokanović M, Prostran M (2009). "Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds". Current Medicinal Chemistry. 16 (17): 2177–88. doi:10.2174/092986709788612729. PMID 19519385.

[1] Jokanović M, Stojiljković MP (December 2006). "Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning". European Journal of Pharmacology. 553 (1–3): 10–7. doi:10.1016/j.ejphar.2006.09.054. PMID 17109842.

[pmid19519385-2] Jokanović M, Prostran M (2009). "Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds". Current Medicinal Chemistry. 16 (17): 2177–88. doi:10.2174/092986709788612729. PMID 19519385.

[1]

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