Procarbazine

Procarbazine
Clinical data
Trade names	Matulane, Natulan, Indicarb, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682094
Pregnancy; category	AU: D;
Routes of; administration	By mouth (gel capsule), intravenous
ATC code	L01XB01 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Metabolism	liver, kidney
Elimination half-life	10 minutes
Excretion	kidney
Identifiers
	IUPAC name N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide;
CAS Number	671-16-9 ;
PubChem CID	4915;
IUPHAR/BPS	7278;
DrugBank	DB01168 ;
ChemSpider	4746 ;
UNII	35S93Y190K;
KEGG	D08423 ;
ChEBI	CHEBI:71417 ;
ChEMBL	ChEMBL1321 ;
CompTox Dashboard (EPA)	DTXSID4021189 ;
ECHA InfoCard	100.010.531
Chemical and physical data
Formula	C12H19N3O
Molar mass	221.304 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccc(cc1)CNNC)NC(C)C;
	InChI InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16) ; Key:CPTBDICYNRMXFX-UHFFFAOYSA-N ;
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Procarbazine is a chemotherapy medication used for the treatment of Hodgkin lymphoma and brain cancers.^[1] For Hodgkin lymphoma it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine.^[1] It is typically taken by mouth.^[1]

Common side effect include low blood cell counts and vomiting.^[1] Other side effects include tiredness and depression.^[2]^[3] It is not recommended in people with severe liver or kidney problems.^[4] Use in pregnancy is known to harm the baby.^[1] Procarbazine is in the alkylating agents family of medication.^[1] How it works is not clearly known.^[1]

Procarbazine was approved for medical use in the United States in 1969.^[1] It is on the World Health Organization's List of Essential Medicines.^[5]^[6] In the United Kingdom a month of treatment cost the National Health Service 450 to 750 pounds.^[4]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Procarbazine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^ "Procarbazine Capsules 50mg – Summary of Product Characteristics". UK Electronic Medicines Compendium. 24 November 2014. Archived from the original on 20 December 2016.
^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 228. hdl:10665/44053. ISBN 9789241547659.
^ ^a ^b British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 606. ISBN 9780857111562.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[AHFS2016-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Procarbazine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.

[UKlabel2014-2] "Procarbazine Capsules 50mg – Summary of Product Characteristics". UK Electronic Medicines Compendium. 24 November 2014. Archived from the original on 20 December 2016.

[WHO2008-3] World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 228. hdl:10665/44053. ISBN 9789241547659.

[BNF69-4] British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 606. ISBN 9780857111562.

[WHO21st-5] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[WHO22nd-6] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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