Propylthiouracil

Propylthiouracil
Clinical data
Other names	6-n-propylthiouracil (PROP)
AHFS/Drugs.com	Monograph
MedlinePlus	a682465
Pregnancy; category	AU: D;
Routes of; administration	By mouth
ATC code	H03BA02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	80%-95%
Metabolism	?
Elimination half-life	2 hours
Excretion	?
Identifiers
	IUPAC name 6-propyl-2-sulfanylpyrimidin-4-one;
CAS Number	51-52-5 ;
PubChem CID	657298;
IUPHAR/BPS	6650;
DrugBank	DB00550 ;
ChemSpider	571424 ;
UNII	721M9407IY;
KEGG	D00562 ;
ChEBI	CHEBI:8502 ;
ChEMBL	ChEMBL1518 ;
CompTox Dashboard (EPA)	DTXSID5021209 ;
ECHA InfoCard	100.000.095
Chemical and physical data
Formula	C7H10N2OS
Molar mass	170.23 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	219 to 221 °C (426 to 430 °F)
	SMILES S=C1N/C(=C\C(=O)N1)CCC;
	InChI InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11) ; Key:KNAHARQHSZJURB-UHFFFAOYSA-N ;
	(verify)

Propylthiouracil (PTU) is a medication used to treat hyperthyroidism.^[2] This includes hyperthyroidism due to Graves' disease and toxic multinodular goiter.^[2] In a thyrotoxic crisis it is generally more effective than methimazole.^[2] Otherwise it is typically only used when methimazole, surgery, and radioactive iodine is not possible.^[2] It is taken by mouth.^[2]

Common side effects include itchiness, hair loss, parotid swelling, vomiting, muscle pains, numbness, and headache.^[2] Other severe side effects include liver problems and low blood cell counts.^[2] Use during pregnancy may harm the baby.^[2] Propylthiouracil is in the antithyroid family of medications.^[3] It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to triiodothyronine (T3).^[2]

Propylthiouracil came into medical use in the 1940s.^[4] It is on the World Health Organization's List of Essential Medicines.^[5]

^ "Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 12 May 2022. Retrieved 13 May 2022.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Propylthiouracil". The American Society of Health-System Pharmacists. Archived from the original on 27 December 2016. Retrieved 8 December 2016.
^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 493. ISBN 9780857111562.
^ De Groot LJ, Jameson JL (2010). Endocrinology Adult and Pediatric: The Thyroid Gland. Elsevier Health Sciences. p. e202. ISBN 978-0323221535. Archived from the original on 2016-12-26.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[1] "Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 12 May 2022. Retrieved 13 May 2022.

[AHFS2016-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Propylthiouracil". The American Society of Health-System Pharmacists. Archived from the original on 27 December 2016. Retrieved 8 December 2016.

[BNF69-3] British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 493. ISBN 9780857111562.

[4] De Groot LJ, Jameson JL (2010). Endocrinology Adult and Pediatric: The Thyroid Gland. Elsevier Health Sciences. p. e202. ISBN 978-0323221535. Archived from the original on 2016-12-26.

[WHO21st-5] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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