Prostacyclin

Prostacyclin
Clinical data
Trade names	Flolan, Veletri
AHFS/Drugs.com	Monograph
License data	US DailyMed: Epoprostenol_sodium;
Pregnancy; category	AU: B1;
ATC code	B01AC09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Pharmacokinetic data
Elimination half-life	42 seconds
Identifiers
	IUPAC name (Z)-5-[(4R,5R)-5-Hydroxy-4-((S,E)-3-hydroxyoct-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-ylidene]pentanoic acid;
CAS Number	35121-78-9 ;
PubChem CID	5282411;
IUPHAR/BPS	1915;
DrugBank	DB01240 ;
ChemSpider	102770 ;
UNII	DCR9Z582X0;
KEGG	D00106; as salt: D01337;
ChEMBL	ChEMBL1139 ;
CompTox Dashboard (EPA)	DTXSID5022988 ;
Chemical and physical data
Formula	C20H32O5
Molar mass	352.471 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(=O)CCC\C=C1\C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]2O1;
	InChI InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 ; Key:KAQKFAOMNZTLHT-OZUDYXHBSA-N ;
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Prostacyclin (also called prostaglandin I₂ or PGI₂) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator.

When used as a drug, it is also known as epoprostenol.^[1] The terms are sometimes used interchangeably.^[2]

^ "epoprostenol" at Dorland's Medical Dictionary
^ Kermode J, Butt W, Shann F (August 1991). "Comparison between prostaglandin E1 and epoprostenol (prostacyclin) in infants after heart surgery". British Heart Journal. 66 (2): 175–178. doi:10.1136/hrt.66.2.175. PMC 1024613. PMID 1883670.

[1] "epoprostenol" at Dorland's Medical Dictionary

[pmid1883670-2] Kermode J, Butt W, Shann F (August 1991). "Comparison between prostaglandin E1 and epoprostenol (prostacyclin) in infants after heart surgery". British Heart Journal. 66 (2): 175–178. doi:10.1136/hrt.66.2.175. PMC 1024613. PMID 1883670.

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