Protein synthesis inhibitor

A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins.[1]

While a broad interpretation of this definition could be used to describe nearly any compound depending on concentration, in practice, it usually refers to compounds that act at the molecular level on translational machinery (either the ribosome itself or the translation factor),[2] taking advantages of the major differences between prokaryotic and eukaryotic ribosome structures.

  1. ^ Frank Lowy. "Protein Synthesis Inhibitors" (PDF). Columbia University. Retrieved 2021-01-27.
  2. ^ "7.344 Antibiotics, Toxins, and Protein Engineering, Spring 2007". MIT OpenCourseWare.
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