Pyrantel

Pyrantel
Clinical data
Trade names	Pin-X, Combantrin, others
Routes of; administration	by mouth
ATC code	P02CC01 (WHO) QP52AF02 (WHO);
Legal status
Legal status	US: OTC;
Pharmacokinetic data
Bioavailability	poorly absorbed
Identifiers
	IUPAC name 1-Methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine;
CAS Number	15686-83-6 ;
PubChem CID	708857;
DrugBank	DB11156;
ChemSpider	618121;
UNII	4QIH0N49E7;
KEGG	D08451;
ChEBI	CHEBI:8654;
ChEMBL	ChEMBL1626223;
CompTox Dashboard (EPA)	DTXSID5023538 ;
ECHA InfoCard	100.036.143
Chemical and physical data
Formula	C11H14N2S
Molar mass	206.31 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	178 to 179 °C (352 to 354 °F)
	SMILES CN1CCCN=C1/C=C/c2cccs2;
	InChI InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+; Key:YSAUAVHXTIETRK-AATRIKPKSA-N;

Pyrantel is a medication used to treat a number of parasitic worm infections.^[2] This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis.^[2] It is taken by mouth.^[2]

Side effects include nausea, headache, dizziness, trouble sleeping, and rash.^[2] A lower dose should be used in people with liver disease.^[2] While it does not appear to be harmful during pregnancy, it has not been studied for this use.^[3] It is unclear if it is safe for use during breastfeeding.^[2] It is in the antihelmintic family of medications.^[4] It works by paralyzing worms.^[4]

Pyrantel was initially described in 1965.^[5] It is on the World Health Organization's List of Essential Medicines.^[6] Pyrantel is available as a generic medication.^[4] It may also be used to treat worms in a number of other animals.^[5]

^ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 54. ISBN 9781284057560.
^ ^a ^b ^c ^d ^e ^f World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 89, 608. hdl:10665/44053. ISBN 9789241547659.
^ "Pyrantel Use During Pregnancy". Drugs.com. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
^ ^a ^b ^c "Pyrantel Pamoate". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
^ ^a ^b Maddison JE, Page SW, Church DB (2008). Small Animal Clinical Pharmacology. Elsevier Health Sciences. p. 209. ISBN 978-0702028588. Archived from the original on 2016-12-20.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[Ric2015-1] Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 54. ISBN 9781284057560.

[WHO2008-2] ^ ^a ^b ^c ^d ^e ^f World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 89, 608. hdl:10665/44053. ISBN 9789241547659.

[3] "Pyrantel Use During Pregnancy". Drugs.com. Archived from the original on 20 December 2016. Retrieved 8 December 2016.

[AHFS2016-4] "Pyrantel Pamoate". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.

[Mad2008-5] Maddison JE, Page SW, Church DB (2008). Small Animal Clinical Pharmacology. Elsevier Health Sciences. p. 209. ISBN 978-0702028588. Archived from the original on 2016-12-20.

[WHO21st-6] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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