Pyridoxine

Pyridoxine
	Pyridoxine
Clinical data
Other names	vitamin B6, pyridoxol pyridoxine hydrochloride
AHFS/Drugs.com	Monograph
License data	US DailyMed: Pyridoxine;
Pregnancy; category	AU: Exempt;
Routes of; administration	By mouth, intravenous (IV), intramuscular (IM), subcutaneous
ATC code	A11HA02 (WHO) ;
Legal status
Legal status	UK: P (Pharmacy medicines); US: OTC / Rx-only;
Pharmacokinetic data
Elimination half-life	several weeks (see #Metabolism for details)
Identifiers
	IUPAC name 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol;
CAS Number	65-23-6;
PubChem CID	1054;
DrugBank	DB00165;
ChemSpider	1025;
UNII	KV2JZ1BI6Z;
KEGG	D08454;
ChEBI	CHEBI:16709;
ChEMBL	ChEMBL1364;
CompTox Dashboard (EPA)	DTXSID4023541 ;
ECHA InfoCard	100.000.548
Chemical and physical data
Formula	C8H11NO3
Molar mass	169.180 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	159 to 162 °C (318 to 324 °F)
	SMILES OCc1cnc(C)c(O)c1CO;
	InChI InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3 ; Key:LXNHXLLTXMVWPM-UHFFFAOYSA-N;

Pyridoxine (PN)^[4] is a form of vitamin B₆ found commonly in food and used as a dietary supplement. As a supplement it is used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, side effects or complications of isoniazid use, and certain types of mushroom poisoning.^[5] It is used by mouth or by injection.^[5]

It is usually well tolerated.^[5] Occasionally side effects include headache, numbness, and sleepiness.^[5] Normal doses are safe during pregnancy and breastfeeding.^[5] Pyridoxine is in the vitamin B family of vitamins.^[5] It is required by the body to metabolise amino acids, carbohydrates, and lipids.^[5] Sources in the diet include meat, fish, fruit, vegetables, and grain.^[6]

^ Dryhurst G (2012). "Electrochemistry of Biologically Important Pyridines". Electrochemistry of Biological Molecules. Elsevier. p. 562. ISBN 978-0-323-14452-0. Archived from the original on 30 December 2016.
^ "Pyridoxine Use During Pregnancy". Drugs.com. 27 April 2020. Archived from the original on 4 December 2020. Retrieved 6 May 2020.
^ "Pyridoxine 50mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 27 April 2015. Archived from the original on 12 October 2013. Retrieved 6 May 2020.
^ "Vitamin B-6". iupac.qmul.ac.uk. Retrieved 26 September 2024.
^ ^a ^b ^c ^d ^e ^f ^g "Pyridoxine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 30 December 2016. Retrieved 8 December 2016.
^ "Office of Dietary Supplements - Dietary Supplement Fact Sheet: Vitamin B6". ods.od.nih.gov. 11 February 2016. Archived from the original on 12 December 2016. Retrieved 30 December 2016.

[1] Dryhurst G (2012). "Electrochemistry of Biologically Important Pyridines". Electrochemistry of Biological Molecules. Elsevier. p. 562. ISBN 978-0-323-14452-0. Archived from the original on 30 December 2016.

[Drugs.com_pregnancy-2] "Pyridoxine Use During Pregnancy". Drugs.com. 27 April 2020. Archived from the original on 4 December 2020. Retrieved 6 May 2020.

[3] "Pyridoxine 50mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 27 April 2015. Archived from the original on 12 October 2013. Retrieved 6 May 2020.

[4] "Vitamin B-6". iupac.qmul.ac.uk. Retrieved 26 September 2024.

[AHFS2016-5] ^ ^a ^b ^c ^d ^e ^f ^g "Pyridoxine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 30 December 2016. Retrieved 8 December 2016.

[NIH2016-6] "Office of Dietary Supplements - Dietary Supplement Fact Sheet: Vitamin B6". ods.od.nih.gov. 11 February 2016. Archived from the original on 12 December 2016. Retrieved 30 December 2016.

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