Sign of Hertoghe
| Sign of Hertoghe | |
|---|---|
| Other names | Queen Anne's sign |
| Anne of Denmark mourning the death of her son Henry in 1612 | |
| Causes | Hypothyroidism, atopic dermatitis |
| Named after | Eugene Ludovic Christian Hertoghe |
The sign of Hertoghe or Queen Anne's sign is a type of madarosis, more specifically a thinning or loss of the outer third of the eyebrows, and may appear in severe hypothyroidism or atopic dermatitis.[1][2][3] It was also observed in lepromatous leprosy, secondary syphilis,[4][5] hypoparathyroidism,[6] poisoning with either lead or thallium, lupus, or normal aging.[7]
- ^ Ständer, Sonja (2021-03-25). "Atopic Dermatitis". New England Journal of Medicine. 384 (12): 1136–1143. doi:10.1056/NEJMra2023911. PMID 33761208. S2CID 232355341.
- ^ Cite error: The named reference
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AmMed1914was invoked but never defined (see the help page). - ^ Parrino, Daniela; Di Bella, Stefano (2016-03-29). "Hertoghe sign: an hallmark of lepromatous leprosy". QJM: Monthly Journal of the Association of Physicians. 109 (7): 497. doi:10.1093/qjmed/hcw046. ISSN 1460-2393. PMID 27026695.
- ^ Sachdeva, Silonie; Prasher, Pawan (Jan–Feb 2008). "Madarosis: A dermatological marker". Indian Journal of Dermatology, Venereology and Leprology. 74 (1): 74–76. doi:10.4103/0378-6323.38426. hdl:1807/48055. PMID 18187839.
- ^ Kobylianskii, Jane; Gold, Wayne L. (2022-02-14). "Queen Anne sign" (PDF). Canadian Medical Association Journal. 194 (6): E219. doi:10.1503/cmaj.211051. ISSN 1488-2329. PMC 8900800. PMID 35165135. Retrieved 2025-04-03.
- ^ Tekiner, Halil; Yale, Eileen S.; Yale, Steven H. (2021-01-01). "Eponymous signs in toxicology and poisoning in the nineteenth and early twentieth centuries". Toxicology Reports. 8: 1583–1591. Bibcode:2021ToxR....8.1583T. doi:10.1016/j.toxrep.2021.08.003. ISSN 2214-7500. PMC 8414049. PMID 34504778.