RO5256390

RO-5256390
Clinical data
Drug class	Trace amine-associated receptor 1 (TAAR1) partial or full agonist
Identifiers
	IUPAC name (S)-4-((S)-2-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine;
CAS Number	1043495-96-0;
PubChem CID	24963286;
ChemSpider	34959936;
ChEMBL	ChEMBL3684869;
Chemical and physical data
Formula	C13H18N2O
Molar mass	218.300 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NC1=N[C@@H](C[C@@H](C2=CC=CC=C2)CC)CO1;
	InChI InChI=1S/C13H18N2O/c1-2-10(11-6-4-3-5-7-11)8-12-9-16-13(14)15-12/h3-7,10,12H,2,8-9H2,1H3,(H2,14,15)/t10-,12-/m0/s1; Key:IXDKFUBXESWHSL-JQWIXIFHSA-N;

RO5256390 or RO-5256390 is a drug developed by Hoffmann-La Roche which acts as an agonist for the trace amine associated receptor 1 (TAAR1).^[1]^[2] It is a full agonist of the rat, cynomolgus monkey, and human TAAR1, but a partial agonist of the mouse TAAR1.^[1]^[2]

^ ^a ^b Wu R, Li JX (December 2021). "Potential of Ligands for Trace Amine-Associated Receptor 1 (TAAR1) in the Management of Substance Use Disorders". CNS Drugs. 35 (12): 1239–1248. doi:10.1007/s40263-021-00871-4. PMC 8787759. PMID 34766253.
^ ^a ^b Cite error: The named reference RevelMoreauPouzet2013 was invoked but never defined (see the help page).