RO5263397

RO5263397
Clinical data
Other names	RO-5263397; Ro 5263397; Ro-5263397
Drug class	Trace amine-associated receptor 1 (TAAR1) partial or full agonist
Identifiers
	IUPAC name (4S)-4-(3-fluoro-2-methylphenyl)-4,5-dihydro-1,3-oxazol-2-amine;
CAS Number	1357266-05-7;
PubChem CID	56835991;
ChemSpider	35523070;
UNII	Y2P4KD8GDR;
ChEMBL	ChEMBL3781694;
Chemical and physical data
Formula	C10H11FN2O
Molar mass	194.209 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C=CC=C1F)[C@H]2COC(=N2)N;
	InChI InChI=1S/C10H11FN2O/c1-6-7(3-2-4-8(6)11)9-5-14-10(12)13-9/h2-4,9H,5H2,1H3,(H2,12,13)/t9-/m1/s1; Key:IOHOUWIYOVWGHV-SECBINFHSA-N;

RO5263397, or RO-5263397, is a trace amine-associated receptor 1 (TAAR1) partial or full agonist which is used in scientific research.^[1]^[2]^[3]^[4]^[5] It is the most well-studied of all of the synthetic TAAR1 ligands.^[1] In addition to its use in research, RO5263397 is or was under development for potential clinical use as a medication.^[6]^[7]^[8]

^ ^a ^b Wu R, Li JX (December 2021). "Potential of Ligands for Trace Amine-Associated Receptor 1 (TAAR1) in the Management of Substance Use Disorders". CNS Drugs. 35 (12): 1239–1248. doi:10.1007/s40263-021-00871-4. PMC 8787759. PMID 34766253.
^ Schwartz MD, Canales JJ, Zucchi R, Espinoza S, Sukhanov I, Gainetdinov RR (June 2018). "Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases". Expert Opinion on Therapeutic Targets. 22 (6): 513–526. doi:10.1080/14728222.2018.1480723. hdl:11568/930006. PMID 29798691.
^ "RO 5263397 hydrochloride Supplier". Tocris Bioscience. Retrieved 29 October 2024. RO 5263397 hydrochloride is a potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.
^ Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, et al. (May 2013). "A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight". Mol Psychiatry. 18 (5): 543–556. doi:10.1038/mp.2012.57. PMID 22641180.
^ Cite error: The named reference EspinozaLeoSotnikova2018 was invoked but never defined (see the help page).
^ Cite error: The named reference KrogmannPetersvonHardenberg2019 was invoked but never defined (see the help page).
^ Cite error: The named reference DoddCarvalhoPuri2021 was invoked but never defined (see the help page).
^ Cite error: The named reference FowlerKletzlFinel2015 was invoked but never defined (see the help page).

[WuLi2021-1] Wu R, Li JX (December 2021). "Potential of Ligands for Trace Amine-Associated Receptor 1 (TAAR1) in the Management of Substance Use Disorders". CNS Drugs. 35 (12): 1239–1248. doi:10.1007/s40263-021-00871-4. PMC 8787759. PMID 34766253.

[SchwartzCanalesZucchi2018-2] Schwartz MD, Canales JJ, Zucchi R, Espinoza S, Sukhanov I, Gainetdinov RR (June 2018). "Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases". Expert Opinion on Therapeutic Targets. 22 (6): 513–526. doi:10.1080/14728222.2018.1480723. hdl:11568/930006. PMID 29798691.

[Tocris-3] "RO 5263397 hydrochloride Supplier". Tocris Bioscience. Retrieved 29 October 2024. RO 5263397 hydrochloride is a potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.

[RevelMoreauPouzet2013-4] Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, et al. (May 2013). "A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight". Mol Psychiatry. 18 (5): 543–556. doi:10.1038/mp.2012.57. PMID 22641180.

[EspinozaLeoSotnikova2018-5] Cite error: The named reference EspinozaLeoSotnikova2018 was invoked but never defined (see the help page).

[KrogmannPetersvonHardenberg2019-6] Cite error: The named reference KrogmannPetersvonHardenberg2019 was invoked but never defined (see the help page).

[DoddCarvalhoPuri2021-7] Cite error: The named reference DoddCarvalhoPuri2021 was invoked but never defined (see the help page).

[FowlerKletzlFinel2015-8] Cite error: The named reference FowlerKletzlFinel2015 was invoked but never defined (see the help page).

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