Rho(D) immune globulin
A Rhesus (D) immunoglobulin ampoule after administration | |
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| Trade names | AntiD, Rhoclone, RhoGAM, others: |
| Other names | Rh0(D) immune globulin, anti-D (Rh0) immunoglobulin, immunoglobulinum humanum anti–D |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Intramuscular injection |
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Rho(D) immune globulin (RhIG) is a medication used to prevent RhD isoimmunization in mothers who are RhD negative and to treat idiopathic thrombocytopenic purpura (ITP) in people who are Rh positive. [1] RhIG is commonly referred to as 'anti-D'. It is often given both during and following pregnancy.[1] It may also be used when RhD-negative people are given RhD-positive blood.[1] It is given by injection into muscle or a vein.[1] A single dose lasts 12 weeks.[1] It is made from human blood plasma.[2]
Common side effects include fever, headache, pain at the site of injection, and red blood cell breakdown.[1] Other side effects include allergic reactions, kidney problems, and a very small risk of viral infections.[1] In those with ITP, the amount of red blood cell breakdown may be significant.[1] Use is safe with breastfeeding.[1] Rho(D) immune globulin is made up of antibodies to the antigen Rho(D) present on some red blood cells.[1] It is believed to work by blocking a person's immune system from recognizing this antigen.[1]
Rho(D) immune globulin came into medical use in the 1960s,[3] following the pioneering work of John G. Gorman. In 1980, Gorman shared the Lasker-DeBakey Clinical Medical Research Award for pioneering work on the rhesus blood group system.[4]
RhIG is on the World Health Organization's List of Essential Medicines.[5][6]
- ^ a b c d e f g h i j k "Rho(D) Immune Globulin". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
- ^ British National Formulary: BNF 69 (69 ed.). British Medical Association. 2015. p. 871. ISBN 9780857111562.
- ^ Hatfield NT (2007). Broadribb's Introductory Pediatric Nursing. Lippincott Williams & Wilkins. p. 251. ISBN 9780781777063. OCLC 968617246 – via Google Books.
- ^ Probyn A (2022-11-01). "A vial of human serum, an ice box and an illegal flight: how an Australian doctor saved millions of babies' lives". ABC News. Retrieved 2022-11-02.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.