Ricin
| Ricin | |||||||
|---|---|---|---|---|---|---|---|
Ricin structure (PDB: 2AAI). The A chain is shown in blue and the B chain in orange. | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | RCOM_2159910 | ||||||
| Entrez | 8287993 | ||||||
| RefSeq (mRNA) | XM_002534603.1 | ||||||
| RefSeq (Prot) | XP_002534649.1 | ||||||
| UniProt | P02879 | ||||||
| Other data | |||||||
| EC number | 3.2.2.22 | ||||||
| Chromosome | whole genome: 0 - 0.01 Mb | ||||||
| |||||||
| Ribosome-inactivating protein (Ricin A chain) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | RIP | ||||||||
| Pfam | PF00161 | ||||||||
| InterPro | IPR001574 | ||||||||
| PROSITE | PDOC00248 | ||||||||
| SCOP2 | 1paf / SCOPe / SUPFAM | ||||||||
| |||||||||
| Ricin-type beta-trefoil lectin domain (Ricin B chain) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | N/A | ||||||||
| Pfam | PF00652 | ||||||||
| Pfam clan | CL0066 | ||||||||
| PROSITE | IPR000772 | ||||||||
| SCOP2 | 1abr / SCOPe / SUPFAM | ||||||||
| CAZy | CBM13 | ||||||||
| CDD | cd00161 | ||||||||
| |||||||||
Ricin (/ˈraɪsɪn/ RY-sin) is a lectin (a carbohydrate-binding protein) and a highly potent toxin produced in the seeds of the castor oil plant, Ricinus communis. The median lethal dose (LD50) of ricin for mice is around 22 micrograms per kilogram of body mass via intraperitoneal injection. Oral exposure to ricin is far less toxic. An estimated lethal oral dose in humans is approximately one milligram per kilogram of body mass.[1]
Ricin is a toxalbumin and was first described by Peter Hermann Stillmark, the founder of lectinology. Ricin is chemically similar to robin.
- ^ "Ricin (from Ricinus communis) as undesirable substances in animal feed-Scientific Opinion of the Panel on Contaminants in the Food Chain". EFSA Journal. 6 (9). European Food Safety Authority: 726. September 2008. doi:10.2903/j.efsa.2008.726.