Roxarsone

Roxarsone
Names
Preferred IUPAC name
(4-Hydroxy-3-nitrophenyl)arsonic acid
Identifiers
CAS Number
3D model (JSmol)
Beilstein Reference
 1976533
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.004.049
EC Number
  • 204-453-7
Gmelin Reference
 1221211
KEGG
MeSH Roxarsone
PubChem CID
RTECS number
  • CY5250000
UNII
UN number 3465
InChI
  • InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12) Y
    Key: XMVJITFPVVRMHC-UHFFFAOYSA-N Y
  • InChI=1/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12)
    Key: XMVJITFPVVRMHC-UHFFFAOYAF
SMILES
  • Oc1ccc(cc1[N+](=O)[O-])[As](O)(O)=O
  • OC1=CC=C(C=C1[N+]([O-])=O)[As](O)(O)=O
Properties
Chemical formula
 C
6AsNH
6O
6
Molar mass 263.0365 g mol−1
Melting point > 300 °C (572 °F; 573 K)
Hazards
GHS labelling:
Pictograms
Signal word
 Danger
Hazard statements
 H301, H331, H410
Precautionary statements
 P261, P273, P301+P310, P311, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references

Roxarsone is an organoarsenic compound that has been used in poultry production and to a lesser extent in pig production as a feed additive to increase weight gain, for greater feed efficiency, to improve pigmentation, and as a coccidiostat.[1][2] Until June 2011, it was approved for use in the United States, Canada, Australia, and 12 other countries.[2] It is no longer approved for use in most jurisdictions.[3]

Roxarsone has been banned in the European Union since 1999.[4] Its use in the United States was voluntarily ended by the manufacturers in June 2011, and it has been illegal since 2013.[5][6] Its use was suspended in Malaysia in June 2011.[7] It was banned in Canada in August 2011.[8] In Australia, its use was discontinued in 2012.[9]

  1. ^ U.S. Food and Drug Administration (June 8, 2011). "Questions and Answers Regarding 3-Nitro (Roxarsone)". Archived from the original on June 12, 2011.
  2. ^ a b Harris, Gardiner; Grady, Denise (9 June 2011). "Pfizer Suspends Sales of Chicken Drug". The New York Times. Retrieved 19 October 2018.
  3. ^ Baynes, Ronald E.; Dedonder, Keith D.; Kissell, Lindsey W.; Mzyk, Danielle A.; Marmulak, Tara; Smith, Geoffrey; Tell, Lisa A.; Gehring, Ronette; Davis, Jennifer L.; Riviere, Jim E. (2016). "Health concerns and management of select veterinary drug residues". Food and Chemical Toxicology. 88: 112–122. doi:10.1016/j.fct.2015.12.020.
  4. ^ Philpott, Tom (11 June 2011). "Some Arsenic With That Supermarket Chicken?". Mother Jones. Retrieved 19 October 2018.
  5. ^ Cite error: The named reference withdrawn was invoked but never defined (see the help page).
  6. ^ "Arsenic in Chicken: Does chicken meat contain arsenic?". Chicken Check In. 21 July 2017. Retrieved 20 March 2018.
  7. ^ "Malaysian Pharmaceutical Society". Malaysian Pharmaceutical Society. Retrieved 19 October 2018.
  8. ^ "Sales halted after arsenic found in chicken drug". The Globe and Mail. 3 May 2018. Retrieved 19 October 2018.
  9. ^ "Roxarsone not used in the Australian chicken industry" (PDF). Australian Meat Chicken Federation. 24 May 2018. Retrieved 19 October 2018.
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