Senecavirus
| Senecavirus | |
|---|---|
| Virus classification | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Picornavirales |
| Family: | Picornaviridae |
| Subfamily: | Caphthovirinae |
| Genus: | Senecavirus |
Senecavirus is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Mammals of the order Artiodactyla (even-toed ungulates) serve as natural hosts, with senecaviruses reported in cows, pigs and dolphins. The genus contains two species.[1][2] Senecavirus is a replication-competent oncolytic picornavirus. It has selective tropism for cancers with neuroendocrine features including small cell lung cancer (SCLC) and several pediatric solid tumors including retinoblastoma, neuroblastoma, and medulloblastoma.[3] A Phase I clinical trial of Senecavirus in adults with neuroendocrine tumors showed that senecavirus is apparently safe to administer at doses up to 1E11 vp/kg.[4] It has potential antineoplastic activity.[5][6]
- ^ "Viral Zone". ExPASy. Retrieved 15 June 2015.
- ^ "Virus Taxonomy: 2024 Release". International Committee on Taxonomy of Viruses. Retrieved 12 April 2025.
- ^ Reddy PS, Burroughs KD, Hales LM, Ganesh S, Jones BH, Idamakanti N, Hay C, Li SS, Skele KL, Vasko AJ, Yang J, Watkins DN, Rudin CM, Hallenbeck PL (2007). "Seneca Valley Virus, a Systemically Deliverable Oncolytic Picornavirus, and the Treatment of Neuroendocrine Cancers". JNCI Journal of the National Cancer Institute. 99 (21): 1623–1633. doi:10.1093/jnci/djm198. PMC 5261858. PMID 17971529.
- ^ Cite error: The named reference
RudinPoirier2011was invoked but never defined (see the help page). - ^ National Cancer Institute Definition of Seneca Valley virus-001. National Cancer Institute Retrieved on 2008-10-09.
- ^ Morton CL, Houghton PJ, Kolb EA, et al. (August 2010). "Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program". Pediatr Blood Cancer. 55 (2): 295–303. doi:10.1002/pbc.22535. PMC 3003870. PMID 20582972.