Trimethoprim/sulfamethoxazole

Trimethoprim/sulfamethoxazole
Trimethoprim (top) and sulfamethoxazole (bottom)
Combination of
SulfamethoxazoleSulfonamide antibiotic
TrimethoprimDihydrofolate reductase inhibitor
Clinical data
Trade namesBactrim, Cotrim, Septra, others
Other namesTMP/SMX, Co-trimoxazole (BAN UK)
AHFS/Drugs.comMonograph
License data
Pregnancy
category
Routes of
administration		Oral, Intravenous infusion[2]
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
  (verify)

Trimethoprim/sulfamethoxazole, sold under the trade names Bactrim, Cotrim (a short form of the British Approved Name, Co-trimoxazole) and Septra, among others, is a fixed-dose combination antibiotic medication used to treat a variety of bacterial infections.[2] It consists of one part trimethoprim to five parts sulfamethoxazole.[7] It is used to treat urinary tract infections, methicillin-resistant Staphylococcus aureus (MRSA) skin infections, travelers' diarrhea, respiratory tract infections, and cholera, among others.[2][7] It is used both to treat and prevent pneumocystis pneumonia and toxoplasmosis in people with HIV/AIDS and other causes of immunosuppression.[2] It can be given orally (swallowed by mouth) or intravenous infusion (slowly injected into a vein with an IV).[2]

Trimethoprim/sulfamethoxazole is on the World Health Organization's List of Essential Medicines.[8] It is available as a generic medication.[7][9] In 2022, it was the 143rd most commonly prescribed medication in the United States, with more than 3 million prescriptions.[10][11]

  1. ^ "Sulfamethoxazole / trimethoprim Use During Pregnancy". Drugs.com. 8 March 2019. Archived from the original on 6 September 2015. Retrieved 15 April 2020.
  2. ^ a b c d e "Co-trimoxazole". The American Society of Health-System Pharmacists. Archived from the original on 6 September 2015. Retrieved 1 August 2015.
  3. ^ "Bactrim DS tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 29 December 2021. Retrieved 28 December 2021.
  4. ^ "TGA eBS – Product and Consumer Medicine Information Licence". Archived from the original on 29 December 2021. Retrieved 29 December 2021.
  5. ^ "Co-Trimoxazole 80 mg/400 mg Tablets – Summary of Product Characteristics (SmPC)". (emc). 1 August 2021. Archived from the original on 29 December 2021. Retrieved 28 December 2021.
  6. ^ "Bactrim DS- sulfamethoxazole and trimethoprim tablet Bactrim- sulfamethoxazole and trimethoprim tablet". DailyMed. Archived from the original on 29 December 2021. Retrieved 28 December 2021.
  7. ^ a b c Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 105. ISBN 978-1-284-05756-0.
  8. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  9. ^ Cite error: The named reference Brown2019 was invoked but never defined (see the help page).
  10. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  11. ^ "Sulfamethoxazole; Trimethoprim Drug Usage Statistics, United States, 2013–2022". ClinCalc. Retrieved 30 August 2024.
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