Enterotoxin type B

Enterotoxin type B
Identifiers
OrganismStaphylococcus aureus
SymbolentB
UniProtP01552
Search for
StructuresSwiss-model
DomainsInterPro
Staphylococcal/Streptococcal toxin, N-terminal domain
Crystal structure of the superantigen Spe-H (zinc bound) from Streptococcus pyogenes
Identifiers
SymbolStaphylococcal/Streptococcal toxin, N-terminal domain
PfamPF01123
Pfam clanCL0658
ECOD2.2.1
InterProIPR006173
PROSITEPDOC00250
SCOP21se3 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Staphylococcal/Streptococcal toxin, beta-grasp domain
Identifiers
SymbolStap_Strp_tox_C
PfamPF02876
InterProIPR006123
PROSITEPDOC00250
SCOP21se3 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In the field of molecular biology, enterotoxin type B, also known as Staphylococcal enterotoxin B (SEB), is an enterotoxin produced by the gram-positive bacteria Staphylococcus aureus. It is a common cause of food poisoning, with severe diarrhea, nausea and intestinal cramping often starting within a few hours of ingestion.[1] Being quite stable,[2] the toxin may remain active even after the contaminating bacteria are killed. It can withstand boiling at 100 °C for a few minutes.[1] Gastroenteritis occurs because SEB is a superantigen, causing the immune system to release a large amount of cytokines that lead to significant inflammation.

Additionally, this protein is one of the causative agents of toxic shock syndrome.

  1. ^ a b "eMedicine - CBRNE - Staphylococcal Enterotoxin B". eMedicine. Retrieved 2011-02-06.
  2. ^ Nema V, Agrawal R, Kamboj DV, Goel AK, Singh L (June 2007). "Isolation and characterization of heat resistant enterotoxigenic Staphylococcus aureus from a food poisoning outbreak in Indian subcontinent". Int. J. Food Microbiol. 117 (1): 29–35. doi:10.1016/j.ijfoodmicro.2007.01.015. PMID 17477998.
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