Subacute thyroiditis

Not to be confused with subacute granulomatous thyroiditis which is commonly known as subacute thyroiditis.
Subacute thyroiditis
Micrograph showing a granuloma in subacute granulomatous thyroiditis. H&E stain.
SpecialtyEndocrinology 

Subacute thyroiditis refers to a temporal classification of the different forms of thyroiditis based on onset of symptoms.[1][2][3][4][5][6][7] The temporal classification of thyroiditis includes presentation of symptoms in an acute, subacute, or chronic manner.[1][2][3][4][5] There are also other classification systems for thyroiditis based on factors such as clinical symptoms and underlying etiology.[2][4]

Broadly, there are three categories of thyroiditis that can present in a subacute fashion, including subacute granulomatous thyroiditis, subacute lymphocytic thyroiditis, and drug-induced thyroiditis.[3][4] In all three categories, there is inflammation of the thyroid gland causing damage to the thyroid follicular cells which produce and secrete thyroid hormone. This often results in three phases of thyroid dysfunction beginning with initial thyrotoxicosis followed by hypothyroidism before resolution back to normal thyroid function.[1][2][3][4][5] In the thyrotoxic stage, individuals usually complain of fever, myalgia, and may have associated anterior neck pain among other symptoms.[1][2][3][4] In the hypothyroid stage, they may be asymptomatic or experience mild symptoms.[2] In most cases, the thyroid dysfunction is transient and people recover with symptomatic treatment.[1][2][3][4]

  1. ^ a b c d e Hennessey, James v (2000), Feingold, Kenneth R.; Anawalt, Bradley; Blackman, Marc R.; Boyce, Alison (eds.), "Subacute Thyroiditis", Endotext, South Dartmouth (MA): MDText.com, Inc., PMID 25905310, retrieved 2023-09-22
  2. ^ a b c d e f g Quintero, Beatriz Martinez (December 2021). "Thyroiditis: Evaluation and Treatment". American Family Physician. 104 (6): 609–617 – via Clinical Key.
  3. ^ a b c d e f Rothacker, Karen M. (31 May 2018). Thyroid Diseases. Cham, Switzerland: Springer. pp. 277–297. ISBN 978-3-319-45013-1.
  4. ^ a b c d e f g Loscalzo, Joseph (2022). Harrison's Principles of Internal Medicine (21e ed.). United States of America: McGraw Hill. ISBN 9781264268511.
  5. ^ a b c Papadakis, Maxine A. (2024). Current Medical Diagnosis & Treatment 2024 (63e ed.). United States of America: McGraw Hill. ISBN 978-1-2655-5603-7.
  6. ^ Molina, Patricia E. (2018). Endocrine Physiology (5e ed.). United States of America: McGraw-Hill Education. ISBN 978-1-260-01935-3.
  7. ^ Agabegi, Steven (2024). Step-Up to Medicine (6e ed.). Mexico: Wolters Kluwer. pp. 179–220. ISBN 978-1-9751-9271-6.
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