Substance P

Substance P
Identifiers
CAS Number	33507-63-0 ;
ChEBI	CHEBI:80308;
ChEMBL	ChEMBL235363 ;
ChemSpider	33558 ;
ECHA InfoCard	100.046.845
IUPHAR/BPS	2098;
MeSH	Substance+P
PubChem CID	36511;
UNII	675VGV5J1D ;
	InChI InChI= 1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1 Key: ADNPLDHMAVUMIW-CUZNLEPHSA-N ; InChI= 1/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(914,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1 Key: ADNPLDHMAVUMIW-CUZNLEPHBU;
Properties
Chemical formula	C63H98N18O13S
Molar mass	1347.63 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Search for
Structures	Swiss-model
Domains	InterPro

tachykinin, precursor 1
tachykinin, precursor 1
	Spacefilling model of substance P
Identifiers
Symbol	TAC1
Alt. symbols	TAC2, NKNA
NCBI gene	6863
HGNC	11517
OMIM	162320
RefSeq	NM_003182
UniProt	P20366
Other data
Locus	Chr. 7 q21-q22
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues)^[1] and a type of neuropeptide, belonging to the tachykinin family of neuropeptides. It acts as a neurotransmitter and a neuromodulator.^[2]^[3] Substance P and the closely related neurokinin A (NKA) are produced from a polyprotein precursor after alternative splicing of the preprotachykinin A gene. The deduced amino acid sequence of substance P is as follows:^[4]

Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met (RPKPQQFFGLM)

with an amide group at the C-terminus.^[5] Substance P is released from the terminals of specific sensory nerves. It is found in the brain and spinal cord and is associated with inflammatory processes and pain.

^ "Undecapeptide Definition & Meaning". Merriam-Webster. Retrieved 17 November 2022.
^ Harrison S, Geppetti P (Jun 2001). "Substance p". The International Journal of Biochemistry & Cell Biology. 33 (6): 555–76. doi:10.1016/S1357-2725(01)00031-0. PMID 11378438.
^ Datar P, Srivastava S, Coutinho E, Govil G (2004). "Substance P: structure, function, and therapeutics". Current Topics in Medicinal Chemistry. 4 (1): 75–103. doi:10.2174/1568026043451636. PMID 14754378. Archived from the original on 2009-08-17. Retrieved 2008-11-01.
^ Reece JB, Campbell NA (2005). Biology, 7th Edition. San Francisco: Pearson, Benjamin Cummings. ISBN 9780805371468. OCLC 57368924.
^ Wong M, Jeng AY (Jan 1994). "Posttranslational modification of glycine-extended substance P by an alpha-amidating enzyme in cultured sensory neurons of dorsal root ganglia". Journal of Neuroscience Research. 37 (1): 97–102. doi:10.1002/jnr.490370113. PMID 7511706. S2CID 31252390.

[1] "Undecapeptide Definition & Meaning". Merriam-Webster. Retrieved 17 November 2022.

[pmid11378438-2] Harrison S, Geppetti P (Jun 2001). "Substance p". The International Journal of Biochemistry & Cell Biology. 33 (6): 555–76. doi:10.1016/S1357-2725(01)00031-0. PMID 11378438.

[pmid14754378-3] Datar P, Srivastava S, Coutinho E, Govil G (2004). "Substance P: structure, function, and therapeutics". Current Topics in Medicinal Chemistry. 4 (1): 75–103. doi:10.2174/1568026043451636. PMID 14754378. Archived from the original on 2009-08-17. Retrieved 2008-11-01.

[Reece_Campbell2005-4] Reece JB, Campbell NA (2005). Biology, 7th Edition. San Francisco: Pearson, Benjamin Cummings. ISBN 9780805371468. OCLC 57368924.

[pmid7511706-5] Wong M, Jeng AY (Jan 1994). "Posttranslational modification of glycine-extended substance P by an alpha-amidating enzyme in cultured sensory neurons of dorsal root ganglia". Journal of Neuroscience Research. 37 (1): 97–102. doi:10.1002/jnr.490370113. PMID 7511706. S2CID 31252390.

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