Succimer

Succimer
Clinical data
Pronunciation/ˈsʌksɪmər/
Trade namesChemet, others
Other namesDimercaptosuccinic acid
DMSA
(2R,3S)-2,3-Dimercaptosuccinic acid
meso-2,3-Dimercaptosuccinic acid
APRD01236
AHFS/Drugs.comMonograph
License data
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • (2R,3S)-2,3-disulfanylbutanedioic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.005.597
Chemical and physical data
FormulaC4H6O4S2
Molar mass182.21 g·mol−1
3D model (JSmol)
Melting point125 °C (257 °F)
SMILES
  • O=C(O)[C@@H](S)[C@@H](S)C(=O)O
InChI
  • InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+ N
  • Key:ACTRVOBWPAIOHC-XIXRPRMCSA-N

Succimer, sold under the brand name Chemet among others, is a medication tool used to treat lead, mercury, and arsenic poisoning.[4] When it's radiolabeled with technetium-99m, it's used in many types of diagnostic testing.[5]

Common side effects include vomiting, diarrhea, rash, and low blood neutrophil levels.[4] Liver problems and allergic reactions may also occur with use.[4] Whether use during pregnancy is safe for the baby is unclear.[6]

Dimercaptosuccinic acid is in the chelating agent family of medications.[4] It binds to a metal atom, leading to increased clearance from the body via the urine.[4] A full course of Succimer lasts for 19 days of oral administration.[4] A second course should be given when more than two weeks pass after the first course.[4]

Succimer has been used medically since the 1950s.[7][8] It is on the World Health Organization's List of Essential Medicines.[9] In the United States, no generic version was available as of 2015.[10]

  1. ^ "Chemet- succimer capsule". DailyMed. U.S. National Library of Medicine. 12 December 2019. Retrieved 19 June 2022.
  2. ^ "Nephroscan- succimer injection, powder, lyophilized, for solution". DailyMed. U.S. National Library of Medicine. 1 March 2022. Retrieved 19 June 2022.
  3. ^ "Rotop - DMSA- kit for the preparation of technetium tc99m succimer injection injection, powder, lyophilized, for solution". DailyMed. U.S. National Library of Medicine. 9 March 2021. Retrieved 19 June 2022.
  4. ^ a b c d e f g "Succimer". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
  5. ^ Biersack HJ, Grünwald F (2005). Thyroid Cancer. Springer Science & Business Media. p. 213. ISBN 9783540278450. Archived from the original on 2017-01-13.
  6. ^ "Succimer (Chemet) Use During Pregnancy". www.drugs.com. Archived from the original on 16 January 2017. Retrieved 12 January 2017.
  7. ^ Miller AL (June 1998). "Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity". Alternative Medicine Review. 3 (3): 199–207. PMID 9630737.
  8. ^ Chappell WR, Abernathy CO, Calderon RL (1999). Arsenic Exposure and Health Effects III. Elsevier. p. 350. ISBN 9780080527574. Archived from the original on 2017-01-13.
  9. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  10. ^ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 472. ISBN 9781284057560.
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