Suramin

Suramin
Clinical data
Trade names	Antrypol, 309 Fourneau, Bayer 205, others
AHFS/Drugs.com	Drugs.com archive
Routes of; administration	by injection only
ATC code	P01CX02 (WHO) QP51AE02 (WHO);
Identifiers
	IUPAC name 8,8'-{Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}di(1,3,5-naphthalenetrisulfonic acid);
CAS Number	145-63-1 ;
PubChem CID	5361;
IUPHAR/BPS	1728;
DrugBank	DB04786 ;
ChemSpider	5168 ;
UNII	6032D45BEM;
KEGG	C07974 ;
ChEBI	CHEBI:45906 ;
ChEMBL	ChEMBL265502 ;
PDB ligand	SVR (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID1046344 ;
ECHA InfoCard	100.005.145
Chemical and physical data
Formula	C51H40N6O23S6
Molar mass	1297.26 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(Nc1cc(ccc1C)C(=O)Nc3c2c(cc(cc2c(cc3)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c8cccc(NC(=O)Nc7cc(C(=O)Nc6cc(C(=O)Nc5c4c(cc(cc4c(cc5)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)ccc6C)ccc7)c8;
	InChI InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) ; Key:FIAFUQMPZJWCLV-UHFFFAOYSA-N ;
	(what is this?) (verify)

Suramin is a medication used to treat African sleeping sickness and river blindness.^[1]^[2] It is the treatment of choice for sleeping sickness without central nervous system involvement.^[3] It is given by injection into a vein.^[4]

Suramin causes a fair number of side effects.^[4] Common side effects include nausea, vomiting, diarrhea, headache, skin tingling, and weakness.^[2] Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur.^[2] Severe side effects may include low blood pressure, decreased level of consciousness, kidney problems, and low blood cell levels.^[4] It is unclear if it is safe when breastfeeding.^[2]

Suramin was made at least as early as 1916.^[5] It is on the World Health Organization's List of Essential Medicines.^[6] In the United States it can be acquired from the Centers for Disease Control (CDC).^[3] In regions of the world where the disease is common suramin is provided for free by the World Health Organization (WHO).^[7]

^ "Suramin Injection Advanced Patient Information". Drugs.com. 3 January 2020. Retrieved 11 January 2020.
^ ^a ^b ^c ^d "Micromedex Detailed Drug Information for the Consumer: Suramin (Injection route)". PubMed Health. 1 November 2016. Archived from the original on 8 September 2017.
^ ^a ^b "Our Formulary Infectious Diseases Laboratories CDC". www.cdc.gov. 22 September 2016. Archived from the original on 16 December 2016. Retrieved 30 November 2016.
^ ^a ^b ^c Zuckerman JN (2002). Principles and Practice of Travel Medicine. John Wiley & Sons. p. 113. ISBN 9780471490791. Archived from the original on 30 November 2016.
^ Mehlhorn H (2008). Encyclopedia of Parasitology: A-M. Springer Science & Business Media. p. 475. ISBN 9783540489948. Archived from the original on 30 November 2016.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ "Trypanosomiasis, human African (sleeping sickness)". World Health Organization. February 2016. Archived from the original on 4 December 2016. Retrieved 7 December 2016.