Tumor-associated glycoprotein 72

Tumor-associated glycoprotein 72 (TAG-72) is a glycoprotein that appears on the surface of many cancer cells, including those from the ovary,[1][2][3] breast, colon,[4] lung, and pancreatic cancers.[5][6] TAG-72 is a mucin-like molecule with a molar mass of over 1000 kDa, and is classified as a tumor-associated glycoprotein.[7]

  1. ^ Ponnusamy MP, Venkatraman G, Singh AP, Chauhan SC, Johansson SL, Jain M, et al. (2007-06-28). "Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis". Cancer Letters. 251 (2): 247–257. doi:10.1016/j.canlet.2006.11.025. PMID 17210225.
  2. ^ Murad JP, Kozlowska AK, Lee HJ, Ramamurthy M, Chang WC, Yazaki P, et al. (2018-11-19). "Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells". Frontiers in Immunology. 9: 2268. doi:10.3389/fimmu.2018.02268. PMC 6254427. PMID 30510550.
  3. ^ Shu R, Evtimov VJ, Hammett MV, Nguyen NN, Zhuang J, Hudson PJ, et al. (2021-01-16). "Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer". Molecular Therapy Oncolytics. 20: 325–341. doi:10.1016/j.omto.2021.01.002. PMC 7868933. PMID 33614914.
  4. ^ Hege KM, Bergsland EK, Fisher GA, Nemunaitis JJ, Warren RS, McArthur JG, et al. (2017-03-21). "Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer". Journal for Immunotherapy of Cancer. 5 22. doi:10.1186/s40425-017-0222-9. PMC 5360066. PMID 28344808.
  5. ^ TAG-72 antigen entry in the public domain NCI Dictionary of Cancer Terms
  6. ^ Scott AM, Wolchok JD, Old LJ (Mar 2012). "Antibody therapy of cancer". Nature Reviews. Cancer. 12 (4): 278–287. doi:10.1038/nrc3236. PMID 22437872. S2CID 205469234.
  7. ^ Sheer DG, Schlom J, Cooper HL (Dec 1988). "Purification and Composition of the Human Tumor-associated Glycoprotein (TAG-72) Defined by Monoclonal Antibodies CC49 and B72.3". Cancer Research. 48 (23): 6811–6818. PMID 3180090.
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