Tenoxicam

Tenoxicam
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	M01AC02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only);
Pharmacokinetic data
Protein binding	High
Elimination half-life	30–140 hours
Identifiers
	IUPAC name (3E)-3-[hydroxy(pyridin-2-ylamino)methylene] -2-methyl-2,3-dihydro-4H-thieno[2,3-e] [1,2]thiazin-4-one 1,1-dioxide;
CAS Number	59804-37-4 ;
PubChem CID	5282194;
DrugBank	DB00469 ;
ChemSpider	4471584 ;
UNII	Z1R9N0A399;
KEGG	D01767 ;
ChEBI	CHEBI:32192 ;
CompTox Dashboard (EPA)	DTXSID8045486 ;
ECHA InfoCard	100.149.365
Chemical and physical data
Formula	C13H11N3O4S2
Molar mass	337.37 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	209 to 213 °C (408 to 415 °F) (dec.)
	SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O;
	InChI InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18); Key:LZNWYQJJBLGYLT-UHFFFAOYSA-N;
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Tenoxicam, sold under the brand name Mobiflex among others, is a nonsteroidal anti-inflammatory drug (NSAID). It is used to relieve inflammation, swelling, stiffness, and pain associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (a type of arthritis involving the spine), tendinitis (inflammation of a tendon), bursitis (inflammation of a bursa, a fluid-filled sac located around joints and near the bones), and periarthritis of the shoulders or hips (inflammation of tissues surrounding these joints).^[1]

Tenoxicam belongs to the class of NSAIDs known as oxicams.

It was patented in 1974 by Roche and approved for medical use in 1987.^[2] It is available as a prescription-only drug in the United Kingdom and other countries, but not in the US. Outside the United Kingdom, tenoxicam is also marketed under brand names including Tilatil, Tilcitin, and Alganex.^[1]^[3]

^ ^a ^b "Medicines A-Z - Tenoxicam". NHS. Retrieved July 3, 2015.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 519. ISBN 9783527607495.
^ "Drugs.com international listings for Tenoxicam". Drugs.com. Retrieved July 3, 2015.

[NHS-1] "Medicines A-Z - Tenoxicam". NHS. Retrieved July 3, 2015.

[Fis2006-2] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 519. ISBN 9783527607495.

[3] "Drugs.com international listings for Tenoxicam". Drugs.com. Retrieved July 3, 2015.

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