Teriparatide

Teriparatide
Clinical data
Trade namesForteo, Forsteo
BiosimilarsBonsity,[1] Kauliv,[2] Livogiva,[3] Osnuvo,[4] Qutavina,[5] Sondelbay,[6] Teribone,[7]
AHFS/Drugs.comMonograph
MedlinePlusa603018
License data
Pregnancy
category
Routes of
administration		Subcutaneous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability95%
MetabolismLiver (nonspecific proteolysis)
Elimination half-lifeSubcutaneous: 1 hour
ExcretionKidney (metabolites)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.168.733
Chemical and physical data
FormulaC181H291N55O51S2
Molar mass4117.77 g·mol−1
3D model (JSmol)
SMILES
  • [H]/N=C(\N)/NCCC[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN/C(=N/[H])/N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc4ccccc4)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc5cnc[nH]5)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](Cc6cnc[nH]6)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)N
InChI
  • InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1 N
  • Key:OGBMKVWORPGQRR-UMXFMPSGSA-N N
 NY (what is this?)  (verify)

Teriparatide, sold under the brand name Forteo, is a form of parathyroid hormone (PTH) consisting of the first (N-terminus) 34 amino acids, which is the portion of the hormone activating the Parathyroid hormone 1 receptor.[12] It is an effective anabolic (promoting bone formation) agent[14] used in the treatment of some forms of osteoporosis.[12][15] Teriparatide is a recombinant human parathyroid hormone analog (PTH 1-34).[12] It has an identical sequence to the 34 N-terminal amino acids of the 84-amino acid human parathyroid hormone.[12]

  1. ^ Cite error: The named reference FDA Bonsity approval was invoked but never defined (see the help page).
  2. ^ a b Cite error: The named reference Kauliv EPAR was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Livogiva EPAR was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference Osnuvo SBD was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference Qutavina EPAR was invoked but never defined (see the help page).
  6. ^ a b Cite error: The named reference Sondelbay EPAR was invoked but never defined (see the help page).
  7. ^ Lisbeth Tristan de Brea (18 September 2018). "Nota de Seguridad de Medicamentos" (PDF). Panama: Directora Nacional de Farmacia y Drogas. Archived (PDF) from the original on 4 December 2020. Retrieved 30 September 2018.
  8. ^ "Terrosa". Therapeutic Goods Administration (TGA). 26 May 2022. Archived from the original on 30 September 2022. Retrieved 7 July 2024.
  9. ^ "Teriparatide Use During Pregnancy". Drugs.com. 25 November 2019. Archived from the original on 27 October 2020. Retrieved 14 September 2020.
  10. ^ "Forteo teriparatide (rbe) 250 microgram solution for injection cartridge, Eli Lilly Australia Pty Ltd, CON-1240". Therapeutic Goods Administration (TGA). 17 June 2024. Archived from the original on 17 June 2024. Retrieved 17 June 2024.
  11. ^ "Ritosa teriparatide 250 microgram/mL solution for injection pre-filled cartridge (408423)". Therapeutic Goods Administration (TGA). 3 May 2024. Archived from the original on 17 June 2024. Retrieved 17 June 2024.
  12. ^ a b c d e "Forteo- teriparatide injection, solution". DailyMed. 29 April 2021. Archived from the original on 19 January 2022. Retrieved 8 March 2023.
  13. ^ Cite error: The named reference Forsteo EPAR was invoked but never defined (see the help page).
  14. ^ Riek AE, Towler DA (2011). "The pharmacological management of osteoporosis". Missouri Medicine. 108 (2): 118–23. PMC 3597219. PMID 21568234.
  15. ^ Saag KG, Shane E, Boonen S, Marín F, Donley DW, Taylor KA, et al. (November 2007). "Teriparatide or alendronate in glucocorticoid-induced osteoporosis". The New England Journal of Medicine. 357 (20): 2028–39. doi:10.1056/NEJMoa071408. PMID 18003959.
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