Thyroid hormone resistance

Thyroid hormone resistance
Other namesResistance to thyroid hormone
Regulation of thyroid hormone
SpecialtyEndocrinology

Thyroid hormone resistance (also resistance to thyroid hormone (RTH), and sometimes Refetoff syndrome) describes a rare syndrome in which the thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed, or not completely suppressed as would be expected. The first report of the condition appeared in 1967.[1] Essentially this is decreased end organ responsiveness to thyroid hormones.[2] A new term "impaired sensitivity to thyroid hormone" has been suggested in March 2014 by Refetoff et al.[3]

  1. ^ Cite error: The named reference pmid4163616 was invoked but never defined (see the help page).
  2. ^ Weiss RE, Dumitrescu A, Refetoff S (2010). "Approach to the patient with resistance to thyroid hormone and pregnancy". J. Clin. Endocrinol. Metab. 95 (7): 3094–102. doi:10.1210/jc.2010-0409. PMC 2928892. PMID 20610605.
  3. ^ Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, et al. (March 2014). "Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism". Eur Thyroid J. 3 (1): 7–9. doi:10.1159/000358180. PMC 4005262. PMID 24847459.
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