Transfusion-related acute lung injury

Transfusion-related acute lung injury
Transfusion-related acute lung injury
Other names	TRALI
	Micrograph of diffuse alveolar damage, the histologic correlate of TRALI; H&E stain
Specialty	Pulmonology

Transfusion-related acute lung injury (TRALI) is the serious complication of transfusion of blood products that is characterized by the rapid onset of excess fluid in the lungs.^[1] It can cause dangerous drops in the supply of oxygen to body tissues. Although changes in transfusion practices have reduced the incidence of TRALI, it was the leading cause of transfusion-related deaths in the United States from fiscal year 2008 through fiscal year 2012.^[2]

^ Gajic, Ognjen; Moore, S. Breanndan (2005). "Transfusion-Related Acute Lung Injury". Mayo Clinic Proceedings. 80 (6): 766–770. doi:10.1016/S0025-6196(11)61531-0. PMID 15945528.
^ U.S. Food and Drug Administration, Center for Biologics Evaluation and Research. Fatalities Reported to FDA Following Blood Collection and Transfusion: Annual Summary for Fiscal Year 2012. Bethesda, Md: U.S. Food and Drug Administration.

[1] Gajic, Ognjen; Moore, S. Breanndan (2005). "Transfusion-Related Acute Lung Injury". Mayo Clinic Proceedings. 80 (6): 766–770. doi:10.1016/S0025-6196(11)61531-0. PMID 15945528.

[2] U.S. Food and Drug Administration, Center for Biologics Evaluation and Research. Fatalities Reported to FDA Following Blood Collection and Transfusion: Annual Summary for Fiscal Year 2012. Bethesda, Md: U.S. Food and Drug Administration.

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