Transmissible gastroenteritis virus

Transmissible gastroenteritis virus
Electron micrograph of transmissible gastroenteritis coronavirus (TGEV)
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Alphacoronavirus
Subgenus: Tegacovirus
Species:
Alphacoronavirus suis
Virus:
Transmissible gastroenteritis virus
Isolates[1]
  • Transmissible gastroenteritis virus virulent Purdue

Transmissible gastroenteritis virus or Transmissible gastroenteritis coronavirus (TGEV) is a coronavirus which infects pigs. It is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the APN receptor.[2] The virus is a member of the genus Alphacoronavirus, subgenus Tegacovirus, species Alphacoronavirus suis.[3][4]

Proteins that contribute to the overall structure of TGEV include the spike (S), envelope (E), membrane (M) and nucleocapsid (N). The genomic size of coronaviruses ranges from approximately 28.6 kilobases.[5] Other coronaviruses that belong to the species Alphacoronavirus suis are Feline coronavirus, Canine coronavirus and Feline infectious peritonitis virus.

  1. ^ "ICTV 9th Report (2011) Coronaviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 26 January 2019. Alphacoronavirus 1 Transmissible gastroenteritis virus Transmissible gastroenteritis virus virulent Purdue [AJ271965] (TGEV virulent Purdue) Species names are in italic script; names of subspecies and isolates are in roman script. Sequence accession numbers [ ] and assigned abbreviations ( ) are also listed.
  2. ^ Fehr AR, Perlman S (2015). "Coronaviruses: an overview of their replication and pathogenesis". In Maier HJ, Bickerton E, Britton P (eds.). Coronaviruses. Methods in Molecular Biology. Vol. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. PMC 4369385. PMID 25720466. See Table 1.
  3. ^ Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna K. P.; Yuen, Kwok-Yung (24 August 2010). "Coronavirus Genomics and Bioinformatics Analysis". Viruses. 2 (8): 1804–1820. doi:10.3390/v2081803. ISSN 1999-4915. PMC 3185738. PMID 21994708. Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein.
  4. ^ "Taxonomy browser (Alphacoronavirus 1)". www.ncbi.nlm.nih.gov. Retrieved 29 February 2020.
  5. ^ Thiel V, ed. (2007). Coronaviruses: Molecular and Cellular Biology (1st ed.). Caister Academic Press. ISBN 978-1-904455-16-5.
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