Tropicamide

Tropicamide
Clinical data
Trade names	Mydriacyl, others
AHFS/Drugs.com	Monograph
License data	US DailyMed: Tropicamide;
Pregnancy; category	C;
Routes of; administration	Topical eye drops
ATC code	S01FA06 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Protein binding	45%
Identifiers
	IUPAC name (RS)-N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide;
CAS Number	1508-75-4 ;
PubChem CID	5593;
IUPHAR/BPS	7319;
DrugBank	DB00809 ;
ChemSpider	5391 ;
UNII	N0A3Z5XTC6;
KEGG	D00397 ;
ChEMBL	ChEMBL1200604 ;
CompTox Dashboard (EPA)	DTXSID8045220 ;
ECHA InfoCard	100.014.673
Chemical and physical data
Formula	C17H20N2O2
Molar mass	284.359 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1;
	InChI InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3; Key:BGDKAVGWHJFAGW-UHFFFAOYSA-N;
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Tropicamide, sold under the brand name Mydriacyl among others, is a medication used to dilate the pupil and help with the examination of the eye.^[3] Specifically it is used to help examine the back of the eye.^[4] It is applied as eye drops.^[3] Effects occur within 40 minutes and last for up to a day.^[3]

Common side effects include blurry vision, increased intraocular pressure, and sensitivity to light.^[3] Another rare but severe side effect is psychosis, particularly in children.^[3] It is unclear if use during pregnancy is safe for the fetus.^[5] Tropicamide is in the antimuscarinic part of the anticholinergic family of medications.^[3] It works by making the muscles within the eye unable to respond to nerve signals.^[3]

Tropicamide was approved for medical use in the United States in 1960.^[3] It is on the World Health Organization's List of Essential Medicines.^[6]

^ "Summary for ARTG Entry: 25356 Mydriacyl tropicamide 0.5% eye drops bottle". Therapeutic Goods Administration. Archived from the original on 5 June 2023. Retrieved 5 June 2023.
^ "Mydriacyl 1% eye drops, solution - Summary of Product Characteristics (SmPC)". Electronic Medicines Compendium. 12 February 2020. Archived from the original on 27 June 2022. Retrieved 29 July 2020.
^ ^a ^b ^c ^d ^e ^f ^g ^h "Tropicamide". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 December 2016. Retrieved 8 December 2016.
^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 314. hdl:10665/44053. ISBN 9789241547659.
^ "Tropicamide ophthalmic Use During Pregnancy". Drugs.com. Archived from the original on 28 December 2016. Retrieved 28 December 2016.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[1] "Summary for ARTG Entry: 25356 Mydriacyl tropicamide 0.5% eye drops bottle". Therapeutic Goods Administration. Archived from the original on 5 June 2023. Retrieved 5 June 2023.

[2] "Mydriacyl 1% eye drops, solution - Summary of Product Characteristics (SmPC)". Electronic Medicines Compendium. 12 February 2020. Archived from the original on 27 June 2022. Retrieved 29 July 2020.

[AHFS2016-3] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Tropicamide". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 December 2016. Retrieved 8 December 2016.

[WHO2008-4] World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 314. hdl:10665/44053. ISBN 9789241547659.

[5] "Tropicamide ophthalmic Use During Pregnancy". Drugs.com. Archived from the original on 28 December 2016. Retrieved 28 December 2016.

[WHO21st-6] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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