Type I hypersensitivity

Type I hypersensitivity
Other namesImmediate hypersensitivity
Image showing the mechanism of activation of type 1 hypersensitivity in a mast cell.
SpecialtyImmunology

Type I hypersensitivity (or immediate hypersensitivity), in the Gell and Coombs classification of allergic reactions, is an allergic reaction provoked by re-exposure to a specific type of antigen referred to as an allergen.[1] Type I is distinct from type II, type III and type IV hypersensitivities. The relevance of the Gell and Coombs classification of allergic reactions has been questioned in the modern-day understanding of allergy, and it has limited utility in clinical practice.[2]

Exposure may be by ingestion, inhalation, injection, or direct contact.

  1. ^ med/1101 at eMedicine
  2. ^ Descotes, Jacques; Choquet-Kastylevsky, Geneviève (February 2001). "Gell and Coombs's classification: is it still valid?". Toxicology. 158 (1–2): 43–49. Bibcode:2001Toxgy.158...43D. doi:10.1016/S0300-483X(00)00400-5. PMID 11164991.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.