Umifenovir

Umifenovir
Clinical data
Trade names	Arbidol
Other names	AR-1I9514, Russian: Арбидол, Chinese: 阿比朵尔.
Pregnancy; category	C;
Routes of; administration	By mouth (hard capsules, tablets)
ATC code	J05AX13 (WHO) ;
Legal status
Legal status	RU OTC ; CN Rx-only ; BY OTC;
Pharmacokinetic data
Bioavailability	40%
Metabolism	Hepatic, CYP3A4
Elimination half-life	17–21 hours
Excretion	40% excrete as unchanged umifenovir in feces (38.9%) and urine (0.12%)
Identifiers
	IUPAC name ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate;
CAS Number	131707-25-0 ;
PubChem CID	131411;
DrugBank	DB13609 ;
ChemSpider	116151 ;
UNII	93M09WW4RU;
KEGG	D10558;
ChEBI	CHEBI:134730;
ChEMBL	ChEMBL1214598;
PDB ligand	75U (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID60895015 ;
ECHA InfoCard	100.247.800
Chemical and physical data
Formula	C22H25BrN2O3S
Molar mass	477.42 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC(=O)c1c(n(c2c1c(c(c(c2)Br)O)CN(C)C)C)CSc3ccccc3;
	InChI InChI=1S/C22H25BrN2O3S/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3/h6-11,26H,5,12-13H2,1-4H3 ; Key:KCFYEAOKVJSACF-UHFFFAOYSA-N ;
	(what is this?) (verify)

Umifenovir, sold under the brand name Arbidol, is sold and used as an antiviral medication for influenza in Russia and China. The drug is manufactured by Pharmstandard (Russian: Фармстандарт). It is not approved by the U.S. Food and Drug Administration (FDA) for the treatment or prevention of influenza.^[6]

^ ^a ^b "阿比朵尔抑制新冠，先声药业生产的吗？". 全民健康网 (in Chinese). Archived from the original on 17 June 2020. Retrieved 17 June 2020.
^ "ИНСТРУКЦИЯ ПО ПРИМЕНЕНИЮ АРПЕТОЛ (ARPETOL)". Vidal (in Belarusian). Archived from the original on 26 January 2018. Retrieved 17 June 2020.
^ ^a ^b Cite error: The named reference pharmk1 was invoked but never defined (see the help page).
^ ^a ^b Cite error: The named reference pharmk2 was invoked but never defined (see the help page).
^ "Full Prescribing Information: Arbidol (umifenovir) film-coated tablets 50 and 100 mg: Corrections and Additions". State Register of Medicines (in Russian). Open joint-stock company "Pharmstandard-Tomskchempharm". Retrieved 3 June 2015.
^ "FDA Approved Drugs for Influenza". U.S. Food and Drug Administration. 8 December 2022. Archived from the original on June 12, 2019.

[qmjkw-1] "阿比朵尔抑制新冠，先声药业生产的吗？". 全民健康网 (in Chinese). Archived from the original on 17 June 2020. Retrieved 17 June 2020.

[2] "ИНСТРУКЦИЯ ПО ПРИМЕНЕНИЮ АРПЕТОЛ (ARPETOL)". Vidal (in Belarusian). Archived from the original on 26 January 2018. Retrieved 17 June 2020.

[pharmk1-3] Cite error: The named reference pharmk1 was invoked but never defined (see the help page).

[pharmk2-4] Cite error: The named reference pharmk2 was invoked but never defined (see the help page).

[5] "Full Prescribing Information: Arbidol (umifenovir) film-coated tablets 50 and 100 mg: Corrections and Additions". State Register of Medicines (in Russian). Open joint-stock company "Pharmstandard-Tomskchempharm". Retrieved 3 June 2015.

[6] "FDA Approved Drugs for Influenza". U.S. Food and Drug Administration. 8 December 2022. Archived from the original on June 12, 2019.

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