Vascular-targeting agent

A vascular-targeting agent (VTA) or vascular disrupting agent (VDA) is a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.[1]

VTAs can be small-molecule or ligand-based.

Small-molecule VTAs include:

  1. ^ Thorpe, Philip E. (2004). "Vascular Targeting Agents as Cancer Therapeutics" (PDF). Clinical Cancer Research. 10 (2): 415–427. doi:10.1158/1078-0432.CCR-0642-03. PMID 14760060. S2CID 1739027.
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