Whole-cell vaccine

Whole-cell vaccines are a type of vaccine that has been prepared in the laboratory from entire cells.[1] Such vaccines simultaneously contain multiple antigens to activate the immune system. They induce antigen-specific T-cell responses.[2]

Whole-cell vaccines have been researched in the fields of bacterial infectious disease (as an inactivated vaccine)[3] and cancer (as tumor cells modified to stimulate the immune system by secreting stimulatory molecules).[2] One whole-cell vaccine that sees global use is the whole-cell pertussis vaccine.[3]

  1. ^ "Whole cell vaccine". National Cancer Institute. Retrieved 14 October 2022.
  2. ^ a b Bridget P., keenan; Elizabeth M., Jaffee (2012). "Whole cell vaccines-past progress and future strategies". Seminars in Oncology. 39 (3): 276–286. doi:10.1053/j.seminoncol.2012.02.007. PMC 3356993. PMID 22595050.
  3. ^ a b Cite error: The named reference :3 was invoked but never defined (see the help page).
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