Apolipoprotein A-II

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ApoA-II
ApoA-II
	structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
Symbol	ApoA-II
Pfam	PF04711
InterPro	IPR006801
SCOP2	1l6k / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

APOA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L6L, 2OU1
Identifiers
Aliases	APOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
External IDs	OMIM: 107670; MGI: 88050; HomoloGene: 1242; GeneCards: APOA2; OMA:APOA2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,223,631 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,053,948 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; epithelium of colon; ; testicle; ; monocyte; ; gonad; ; bone marrow cell; ; granulocyte; ; left uterine tube; ; tendon of biceps brachii; ; blood;
	Top expressed in
	left lobe of liver; ; yolk sac; ; fetal liver hematopoietic progenitor cell; ; human fetus; ; abdominal wall; ; right kidney; ; embryo; ; blastocyst; ; proximal tubule; ; sexually immature organism;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lipase inhibitor activity; protein homodimerization activity; phosphatidylcholine binding; lipid transporter activity; apolipoprotein receptor binding; high-density lipoprotein particle receptor binding; cholesterol binding; protein binding; protein heterodimerization activity; phosphatidylcholine-sterol O-acyltransferase activator activity; phospholipid binding; cholesterol transfer activity; lipid binding; high-density lipoprotein particle binding; heat shock protein binding; signaling receptor binding;
Cellular component	cytosol; blood microparticle; endoplasmic reticulum lumen; chylomicron; very-low-density lipoprotein particle; spherical high-density lipoprotein particle; extracellular region; early endosome; high-density lipoprotein particle; extracellular exosome; extracellular space;
Biological process	negative regulation of cholesterol import; negative regulation of very-low-density lipoprotein particle remodeling; diacylglycerol catabolic process; lipid transport; regulation of protein stability; positive regulation of cholesterol esterification; phospholipid efflux; cholesterol transport; positive regulation of lipid catabolic process; response to glucocorticoid; negative regulation of cytokine production involved in immune response; response to glucose; high-density lipoprotein particle assembly; retinoid metabolic process; response to estrogen; high-density lipoprotein particle remodeling; negative regulation of lipase activity; regulation of intestinal cholesterol absorption; low-density lipoprotein particle remodeling; acute inflammatory response; animal organ regeneration; phospholipid catabolic process; peptidyl-methionine modification; cholesterol efflux; negative regulation of cholesterol transport; cholesterol homeostasis; phosphatidylcholine biosynthetic process; negative regulation of cholesterol transporter activity; viral process; negative regulation of lipid catabolic process; triglyceride-rich lipoprotein particle remodeling; triglyceride metabolic process; reverse cholesterol transport; high-density lipoprotein particle clearance; positive regulation of catalytic activity; cholesterol metabolic process; regulation of lipid metabolic process; chylomicron remodeling; chylomicron assembly; lipoprotein metabolic process; post-translational protein modification; transport; positive regulation of phagocytosis; protein stabilization;
	Sources:Amigo / QuickGO
Orthologs
	336
	11807
	ENSG00000158874
	ENSMUSG00000005681
	P02652
	P09813
	NM_001643
	NM_013474; NM_001305549; NM_001305550; NM_001305585
	NP_001634
	NP_001292478; NP_001292479; NP_001292514; NP_038502
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.^[5] It is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear. ^[6] Remarkably, defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158874 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. doi:10.1016/S0021-9258(18)95725-X. PMID 2415515.
^ Tailleux A, Duriez P, Fruchart JC, Clavey V (September 2002). "Apolipoprotein A-II, HDL metabolism and atherosclerosis". Atherosclerosis. 164 (1): 1–13. doi:10.1016/s0021-9150(01)00751-1. ISSN 0021-9150. PMID 12119188.
^ "Entrez Gene: APOA2 apolipoprotein A-II".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158874 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005681 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2415515-5] Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. doi:10.1016/S0021-9258(18)95725-X. PMID 2415515.

[6] Tailleux A, Duriez P, Fruchart JC, Clavey V (September 2002). "Apolipoprotein A-II, HDL metabolism and atherosclerosis". Atherosclerosis. 164 (1): 1–13. doi:10.1016/s0021-9150(01)00751-1. ISSN 0021-9150. PMID 12119188.

[entrez-7] "Entrez Gene: APOA2 apolipoprotein A-II".

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