Adiponectin

ADIPOQ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DOU
Identifiers
Aliases	ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, C1Q and collagen domain containing, Adiponectin
External IDs	OMIM: 605441; MGI: 106675; HomoloGene: 3525; GeneCards: ADIPOQ; OMA:ADIPOQ - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	186,858,463 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,976,778 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; pericardium; ; skin of hip; ; adipose tissue; ; subcutaneous adipose tissue; ; abdominal fat; ; parotid gland; ; lactiferous duct; ; Skeletal muscle tissue of rectus abdominis; ; vena cava;
	Top expressed in
	white adipose tissue; ; lactiferous gland; ; tunica adventitia of aorta; ; brown adipose tissue; ; subcutaneous adipose tissue; ; intercostal muscle; ; ankle joint; ; parotid gland; ; ankle; ; tunica media of zone of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity; signaling receptor binding; cytokine activity; sialic acid binding; protein homodimerization activity; protein binding; identical protein binding; extracellular matrix structural constituent;
Cellular component	cell surface; endoplasmic reticulum; collagen; extracellular space; extracellular region; protein-containing complex; collagen-containing extracellular matrix;
Biological process	positive regulation of glucose import; positive regulation of protein phosphorylation; negative regulation of receptor binding; low-density lipoprotein particle clearance; negative regulation of blood pressure; negative regulation of macrophage differentiation; negative regulation of synaptic transmission; generation of precursor metabolites and energy; cellular response to epinephrine stimulus; negative regulation of gluconeogenesis; regulation of glucose metabolic process; circadian rhythm; fatty acid oxidation; positive regulation of interleukin-8 production; glucose metabolic process; protein heterotrimerization; negative regulation of heterotypic cell-cell adhesion; response to ethanol; negative regulation of inflammatory response; cellular response to cAMP; positive regulation of protein kinase A signaling; negative regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of signal transduction; positive regulation of protein metabolic process; negative regulation of fat cell differentiation; response to linoleic acid; detection of oxidative stress; glucose homeostasis; adiponectin-activated signaling pathway; response to tumor necrosis factor; positive regulation of blood pressure; response to nutrient levels; positive regulation of cholesterol efflux; negative regulation of MAP kinase activity; cellular response to insulin stimulus; positive regulation of peptidyl-tyrosine phosphorylation; fatty acid beta-oxidation; negative regulation of tumor necrosis factor production; protein localization to plasma membrane; negative regulation of hormone secretion; protein homooligomerization; response to sucrose; positive regulation of metanephric glomerular visceral epithelial cell development; positive regulation of renal albumin absorption; negative regulation of granulocyte differentiation; response to nutrient; negative regulation of protein autophosphorylation; negative regulation of intracellular protein transport; membrane depolarization; response to glucose; positive regulation of myeloid cell apoptotic process; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of metanephric mesenchymal cell migration; negative regulation of cell migration; positive regulation of fatty acid metabolic process; brown fat cell differentiation; positive regulation of cAMP-dependent protein kinase activity; positive regulation of glycogen (starch) synthase activity; negative regulation of transcription, DNA-templated; negative regulation of DNA biosynthetic process; positive regulation of protein kinase activity; response to hypoxia; negative regulation of phagocytosis; membrane hyperpolarization; negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of monocyte chemotactic protein-1 production; response to glucocorticoid; response to activity; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of ERK1 and ERK2 cascade; negative regulation of macrophage derived foam cell differentiation; regulation of fatty acid biosynthetic process; regulation of signaling receptor activity; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell migration; response to bacterium; positive regulation of cold-induced thermogenesis; negative regulation of cold-induced thermogenesis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9370
	11450
	ENSG00000181092
	ENSMUSG00000022878
	Q15848
	Q60994
	NM_001177800; NM_004797
	NM_009605
	NP_001171271; NP_004788
	NP_033735
	Wikidata
View/Edit Human	View/Edit Mouse

Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels and fatty acid breakdown.^[5]^[6] In humans, it is encoded by the ADIPOQ gene and is produced primarily in adipose tissue, but also in muscle and even in the brain.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181092 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022878 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y (June 2017). "Obesity and inflammation: the linking mechanism and the complications". Archives of Medical Science. 13 (4): 851–863. doi:10.5114/aoms.2016.58928. PMC 5507106. PMID 28721154.
^ Amerikanou C, Kaliora AC, Gioxari A (December 2021). "The efficacy of Panax ginseng in obesity and the related metabolic disorders". Pharmacological Research - Modern Chinese Medicine. 1: 100013. doi:10.1016/j.prmcm.2021.100013. ISSN 2667-1425.
^ Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (April 1996). "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)". Biochemical and Biophysical Research Communications. 221 (2): 286–289. doi:10.1006/bbrc.1996.0587. PMID 8619847.
^ Martinez-Huenchullan SF, Tam CS, Ban LA, Ehrenfeld-Slater P, Mclennan SV, Twigg SM (January 2020). "Skeletal muscle adiponectin induction in obesity and exercise". Metabolism. 102: 154008. doi:10.1016/j.metabol.2019.154008. PMID 31706980.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181092 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022878 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y (June 2017). "Obesity and inflammation: the linking mechanism and the complications". Archives of Medical Science. 13 (4): 851–863. doi:10.5114/aoms.2016.58928. PMC 5507106. PMID 28721154.

[6] Amerikanou C, Kaliora AC, Gioxari A (December 2021). "The efficacy of Panax ginseng in obesity and the related metabolic disorders". Pharmacological Research - Modern Chinese Medicine. 1: 100013. doi:10.1016/j.prmcm.2021.100013. ISSN 2667-1425.

[pmid8619847-7] Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (April 1996). "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)". Biochemical and Biophysical Research Communications. 221 (2): 286–289. doi:10.1006/bbrc.1996.0587. PMID 8619847.

[pmid31706980-8] Martinez-Huenchullan SF, Tam CS, Ban LA, Ehrenfeld-Slater P, Mclennan SV, Twigg SM (January 2020). "Skeletal muscle adiponectin induction in obesity and exercise". Metabolism. 102: 154008. doi:10.1016/j.metabol.2019.154008. PMID 31706980.

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