Adrenomedullin
Adrenomedullin (ADM) is a peptide hormone that plays an important role in various physiological processes throughout the human body. Initially discovered in 1993 from a pheochromocytoma, a tumor of the adrenal medulla,[5] this 52-amino acid peptide is now recognized for its diverse effects, including vasodilation, regulation of blood pressure, and maintenance of the vascular system.[6] ADM is widely expressed in tissues and also found in the circulation, exerting its influence on the cardiovascular, lymphatic, and endocrine systems, as well as demonstrating anti-inflammatory and tissue-protective properties.[7][8]
In humans ADM is encoded by the ADM gene. A similar peptide named adreomedullin2 was reported in rats in 2004 which exhibits a similar function.[9]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000148926 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030790 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kitamura K, Kato J, Kawamoto M, Tanaka M, Chino N, Kangawa K, et al. (March 1998). "The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma". Biochemical and Biophysical Research Communications. 244 (2): 551–555. doi:10.1006/bbrc.1998.8310. PMID 9514956.
- ^ Sacco MA, Gualtieri S, Cordasco F, Tarallo AP, Verrina MC, Princi A, et al. (August 2024). "The Role of Adrenomedullin as a Predictive Marker of the Risk of Death and Adverse Clinical Events: A Review of the Literature". Journal of Clinical Medicine. 13 (16): 4847. doi:10.3390/jcm13164847. PMC 11355278. PMID 39200990.
- ^ Kita T, Kitamura K (March 2022). "Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases". Hypertension Research. 45 (3): 389–400. doi:10.1038/s41440-021-00806-y. PMC 8732970. PMID 34992239.
- ^ Fischer JP, Els-Heindl S, Beck-Sickinger AG (September 2020). "Adrenomedullin - Current perspective on a peptide hormone with significant therapeutic potential". Peptides. 131: 170347. doi:10.1016/j.peptides.2020.170347. PMID 32569606.
- ^ Fujisawa Y, Nagai Y, Miyatake A, Takei Y, Miura K, Shoukouji T, et al. (August 2004). "Renal effects of a new member of adrenomedullin family, adrenomedullin2, in rats". European Journal of Pharmacology. 497 (1): 75–80. doi:10.1016/j.ejphar.2004.06.039. PMID 15321737.