Amylin

IAPP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KUW, 2G48, 2KB8, 2L86, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 3DG1
Identifiers
Aliases	IAPP, DAP, IAP, islet amyloid polypeptide
External IDs	OMIM: 147940; MGI: 96382; HomoloGene: 36024; GeneCards: IAPP; OMA:IAPP - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,379,980 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,249,687 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; beta cell; ; body of pancreas; ; right lobe of liver; ; left testis; ; right testis; ; duodenum; ; bone marrow; ; female breast; ; lactiferous gland;
	Top expressed in
	islet of Langerhans; ; pyloric antrum; ; embryo; ; migratory enteric neural crest cell; ; human fetus; ; Paneth cell; ; supraoptic nucleus; ; jejunum; ; Rostral migratory stream; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; hormone activity; identical protein binding; amyloid-beta binding; protein binding;
Cellular component	extracellular region; soma; extracellular space; inclusion body;
Biological process	negative regulation of cell differentiation; cell-cell signaling; sensory perception of pain; eating behavior; signal transduction; negative regulation of bone resorption; apoptotic process; negative regulation of cell population proliferation; protein destabilization; protein homooligomerization; amyloid fibril formation; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; regulation of signaling receptor activity; positive regulation of protein kinase A signaling; negative regulation of mitochondrion organization; negative regulation of protein homooligomerization; positive regulation of apoptotic process; positive regulation of MAPK cascade; positive regulation of protein kinase B signaling; amylin receptor signaling pathway; negative regulation of amyloid fibril formation;
	Sources:Amigo / QuickGO
Orthologs
	3375
	15874
	ENSG00000121351
	ENSMUSG00000041681
	P10997
	P12968
	NM_000415; NM_001329201
	NM_010491
	NP_000406; NP_001316130
	NP_034621
	Wikidata
View/Edit Human	View/Edit Mouse

Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone.^[5] It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.

IAPP is processed from an 89-residue coding sequence. Proislet amyloid polypeptide (proIAPP, proamylin, proislet protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121351 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IAPP islet amyloid polypeptide".
^ Higham CE, Hull RL, Lawrie L, Shennan KI, Morris JF, Birch NP, et al. (August 2000). "Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro". European Journal of Biochemistry. 267 (16): 4998–5004. doi:10.1046/j.1432-1327.2000.01548.x. PMID 10931181.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121351 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041681 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: IAPP islet amyloid polypeptide".

[Higham-6] Higham CE, Hull RL, Lawrie L, Shennan KI, Morris JF, Birch NP, et al. (August 2000). "Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro". European Journal of Biochemistry. 267 (16): 4998–5004. doi:10.1046/j.1432-1327.2000.01548.x. PMID 10931181.

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