Anti-histone antibodies

Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family, which specifically target histone protein subunits or histone complexes.[1] They were first reported by Henry Kunkel, H.R. Holman, and H.R.G. Dreicher in their studies of cellular causes of lupus erythematosus in 1959–60.[2][3] Today, anti-histone antibodies are still used as a marker for systemic lupus erythematosus, but are also implicated in other autoimmune diseases like Sjögren syndrome, dermatomyositis, or rheumatoid arthritis.[4][5] Anti-histone antibodies can be used as a marker for drug-induced lupus.

  1. ^ Muller, Sylviane (2014). Chapter 23 - Histone Autoantibodies, In Autoantibodies (Third ed.). San Diego, CA. p. 195. doi:10.1016/B978-0-444-56378-1.00023-X. ISBN 9780444563781.{{cite book}}: CS1 maint: location missing publisher (link)
  2. ^ Holman, Henry R.; Deicher, H.R.G.; Kunkel, H.G. (July 1959). "The L.E. Cell and L.E. Serum Factors". Bulletin of the New York Academy of Medicine. 35 (7): 409–418. PMC 1806184. PMID 13662729.
  3. ^ Holman, H.R.; Deicher, H.R.G.; Kunkel, H.G. (January 1, 1960). Chapter 20. Multiple "Autoantibodies" to Cell Constituents in Systematic Lupus Erythematosus. In: Ciba Foundation Symposium - Cellular Aspects of Immunity. Chichester, UK: John Wiley & Sons. pp. 429–449. doi:10.1002/9780470719169.ch20.
  4. ^ Kumar, Vinay; Abbas, Abul; Aster, Jon (2018). Robbins Basic Pathology (10 ed.). Philadelphia, PA: Elsevier. pp. 150–157. ISBN 978-0-323-35317-5.
  5. ^ Inova Diagnostics. "Quanta Lite Histone". Inova Diagnostics a Werfen Company. Retrieved 8 February 2018.
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