Apolipoprotein AI

APOA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AV1, 1GW3, 1GW4, 1ODP, 1ODQ, 1ODR, 2A01, 3K2S, 3R2P, 2MSC, 2MSD, 2MSE, 4V6M
Identifiers
Aliases	APOA1, entrez:335, apo(a), apolipoprotein A1, Apolipoprotein A-I, HPALP2
External IDs	OMIM: 107680; MGI: 88049; HomoloGene: 47900; GeneCards: APOA1; OMA:APOA1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	116,837,622 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	46,141,764 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; mucosa of ileum; ; right testis; ; left testis; ; duodenum; ; apex of heart; ; gonad; ; left ventricle; ; amniotic fluid;
	Top expressed in
	left lobe of liver; ; jejunum; ; yolk sac; ; duodenum; ; epithelium of stomach; ; gallbladder; ; ileum; ; fetal liver hematopoietic progenitor cell; ; migratory enteric neural crest cell; ; mucous cell of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lipase inhibitor activity; phosphatidylcholine binding; apolipoprotein receptor binding; high-density lipoprotein particle receptor binding; lipoprotein particle binding; phosphatidylcholine-sterol O-acyltransferase activator activity; phospholipid binding; apolipoprotein A-I receptor binding; enzyme binding; cholesterol transfer activity; amyloid-beta binding; phospholipid transporter activity; protein binding; chemorepellent activity; lipid transporter activity; cholesterol binding; identical protein binding; high-density lipoprotein particle binding; lipid binding; heat shock protein binding; signaling receptor binding;
Cellular component	cytosol; endoplasmic reticulum lumen; chylomicron; extracellular region; nucleus; extracellular vesicle; endocytic vesicle lumen; discoidal high-density lipoprotein particle; very-low-density lipoprotein particle; cell surface; secretory granule lumen; extracellular exosome; blood microparticle; endocytic vesicle; plasma membrane; spherical high-density lipoprotein particle; early endosome; high-density lipoprotein particle; cytoplasmic vesicle; extracellular space; low-density lipoprotein particle; intermediate-density lipoprotein particle; collagen-containing extracellular matrix;
Biological process	positive regulation of Rho protein signal transduction; regulation of protein phosphorylation; cholesterol import; lipid transport; negative chemotaxis; positive regulation of cholesterol esterification; phospholipid efflux; phospholipid transport; negative regulation of hydrolase activity; receptor-mediated endocytosis; retinoid metabolic process; negative regulation of lipase activity; regulation of intestinal cholesterol absorption; negative regulation of cell adhesion molecule production; peripheral nervous system axon regeneration; endothelial cell proliferation; animal organ regeneration; peptidyl-methionine modification; cholesterol homeostasis; negative regulation of heterotypic cell-cell adhesion; transforming growth factor beta receptor signaling pathway; negative regulation of inflammatory response; phospholipid homeostasis; ERK1 and ERK2 cascade; negative regulation of cytokine production involved in immune response; positive regulation of fatty acid biosynthetic process; high-density lipoprotein particle clearance; lipoprotein metabolic process; G protein-coupled receptor signaling pathway; positive regulation of triglyceride catabolic process; response to nutrient; glucocorticoid metabolic process; lipid storage; protein stabilization; positive regulation of lipoprotein lipase activity; cholesterol metabolic process; response to estrogen; triglyceride catabolic process; transmembrane transport; transport; cholesterol efflux; integrin-mediated signaling pathway; phosphatidylcholine biosynthetic process; neuron projection regeneration; negative regulation of very-low-density lipoprotein particle remodeling; steroid metabolic process; positive regulation of hydrolase activity; regulation of Cdc42 protein signal transduction; blood vessel endothelial cell migration; negative regulation of tumor necrosis factor-mediated signaling pathway; lipid metabolism; cholesterol transport; platelet degranulation; adrenal gland development; high-density lipoprotein particle assembly; negative regulation of response to cytokine stimulus; high-density lipoprotein particle remodeling; positive regulation of substrate adhesion-dependent cell spreading; phospholipid metabolic process; vitamin transport; cholesterol biosynthetic process; positive regulation of stress fiber assembly; triglyceride homeostasis; reverse cholesterol transport; lipoprotein biosynthetic process; positive regulation of cholesterol efflux; regulation of lipid metabolic process; regulation of cholesterol transport; chylomicron remodeling; very-low-density lipoprotein particle remodeling; chylomicron assembly; post-translational protein modification; positive regulation of lipid biosynthetic process; positive regulation of phagocytosis; positive regulation of phospholipid efflux;
	Sources:Amigo / QuickGO
Orthologs
	335
	11806
	ENSG00000118137
	ENSMUSG00000032083
	P02647
	Q00623
	NM_000039; NM_001318017; NM_001318018; NM_001318021
	NM_009692
NP_000030; NP_001304946; NP_001304947; NP_001304950; NP_000030.1;
	NP_001304946.1; NP_001304947.1
	NP_033822
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the APOA1 gene.^[5]^[6] As the major component of high-density lipoprotein (HDL) particles, it has a specific role in lipid metabolism.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118137 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032083 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Breslow JL, Ross D, McPherson J, Williams H, Kurnit D, Nussbaum AL, et al. (November 1982). "Isolation and characterization of cDNA clones for human apolipoprotein A-I". Proceedings of the National Academy of Sciences of the United States of America. 79 (22): 6861–6865. Bibcode:1982PNAS...79.6861B. doi:10.1073/pnas.79.22.6861. PMC 347233. PMID 6294659.
^ Arinami T, Hirano T, Kobayashi K, Yamanouchi Y, Hamaguchi H (June 1990). "Assignment of the apolipoprotein A-I gene to 11q23 based on RFLP in a case with a partial deletion of chromosome 11, del(11)(q23.3----qter)". Human Genetics. 85 (1): 39–40. doi:10.1007/BF00276323. PMID 1972696. S2CID 22613512.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118137 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032083 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6294659-5] Breslow JL, Ross D, McPherson J, Williams H, Kurnit D, Nussbaum AL, et al. (November 1982). "Isolation and characterization of cDNA clones for human apolipoprotein A-I". Proceedings of the National Academy of Sciences of the United States of America. 79 (22): 6861–6865. Bibcode:1982PNAS...79.6861B. doi:10.1073/pnas.79.22.6861. PMC 347233. PMID 6294659.

[pmid1972696-6] Arinami T, Hirano T, Kobayashi K, Yamanouchi Y, Hamaguchi H (June 1990). "Assignment of the apolipoprotein A-I gene to 11q23 based on RFLP in a case with a partial deletion of chromosome 11, del(11)(q23.3----qter)". Human Genetics. 85 (1): 39–40. doi:10.1007/BF00276323. PMID 1972696. S2CID 22613512.

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