Apolipoprotein B

APOB
Identifiers
Aliases	APOB, FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B, FCHL2
External IDs	OMIM: 107730; MGI: 88052; HomoloGene: 328; GeneCards: APOB; OMA:APOB - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	21,044,073 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	8,066,835 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; liver; ; mucosa of ileum; ; right lobe of liver; ; duodenum; ; right ventricle; ; right auricle of heart; ; myocardium; ; left ventricle; ; cardiac muscle tissue of right atrium;
	Top expressed in
	left lobe of liver; ; jejunum; ; yolk sac; ; duodenum; ; ileum; ; gallbladder; ; primitive streak; ; intestinal epithelium; ; intestinal villus; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; lipid binding; lipid transporter activity; cholesterol transfer activity; lipase binding; low-density lipoprotein particle receptor binding; phospholipid binding; heparin binding; signaling receptor binding;
Cellular component	early endosome; chylomicron remnant; vesicle lumen; endoplasmic reticulum; endosome membrane; mature chylomicron; endoplasmic reticulum lumen; vesicle membrane; endosome lumen; intermediate-density lipoprotein particle; clathrin-coated endocytic vesicle membrane; endoplasmic reticulum membrane; extracellular exosome; endocytic vesicle lumen; soma; cytoplasm; chylomicron; very-low-density lipoprotein particle; low-density lipoprotein particle; endoplasmic reticulum exit site; extracellular space; smooth endoplasmic reticulum; cytosol; plasma membrane; lysosomal lumen; intracellular membrane-bounded organelle; extracellular region; high-density lipoprotein particle;
Biological process	artery morphogenesis; in utero embryonic development; fertilization; receptor-mediated endocytosis; positive regulation of cholesterol storage; lipid metabolism; cholesterol metabolic process; cholesterol transport; regulation of cholesterol biosynthetic process; lipid transport; nervous system development; leukocyte migration; response to carbohydrate; retinoid metabolic process; steroid metabolic process; triglyceride mobilization; lipid catabolic process; response to lipopolysaccharide; positive regulation of macrophage derived foam cell differentiation; cellular response to prostaglandin stimulus; response to virus; positive regulation of lipid storage; cellular response to tumor necrosis factor; response to selenium ion; flagellated sperm motility; positive regulation of gene expression; response to organic substance; cholesterol homeostasis; spermatogenesis; triglyceride catabolic process; cholesterol efflux; post-embryonic development; lipoprotein transport; toll-like receptor signaling pathway; response to estradiol; membrane organization; chylomicron remodeling; low-density lipoprotein particle remodeling; chylomicron assembly; very-low-density lipoprotein particle assembly; chylomicron remnant clearance; low-density lipoprotein particle clearance; very-low-density lipoprotein particle clearance; lipoprotein metabolic process; lipoprotein biosynthetic process; lipoprotein catabolic process; post-translational protein modification; transport;
	Sources:Amigo / QuickGO
Orthologs
	338
	238055
	ENSG00000084674
	ENSMUSG00000020609
	P04114
	E9Q414
	NM_000384
	NM_009693
	NP_000375
	NP_033823
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. Its measurement is commonly used to detect the risk of atherosclerotic cardiovascular disease.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000084674 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020609 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Glavinovic T, Thanassoulis G, de Graaf J, Couture P, Hegele RA, Sniderman AD (October 2022). "Physiological Bases for the Superiority of Apolipoprotein B Over Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk". Journal of the American Heart Association. 11 (20): e025858. doi:10.1161/JAHA.122.025858. PMC 9673669. PMID 36216435.
^ Behbodikhah J, Ahmed S, Elyasi A, Kasselman LJ, De Leon J, Glass AD, et al. (October 2021). "Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target". Metabolites. 11 (10): 690. doi:10.3390/metabo11100690. PMC 8540246. PMID 34677405.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000084674 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020609 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Glavinovic T, Thanassoulis G, de Graaf J, Couture P, Hegele RA, Sniderman AD (October 2022). "Physiological Bases for the Superiority of Apolipoprotein B Over Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk". Journal of the American Heart Association. 11 (20): e025858. doi:10.1161/JAHA.122.025858. PMC 9673669. PMID 36216435.

[6] Behbodikhah J, Ahmed S, Elyasi A, Kasselman LJ, De Leon J, Glass AD, et al. (October 2021). "Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target". Metabolites. 11 (10): 690. doi:10.3390/metabo11100690. PMC 8540246. PMID 34677405.

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