Apolipoprotein C-III

APOC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JQ3
Identifiers
Aliases	APOC3, APOCIII, HALP2, apolipoprotein C3, Apo-C3, ApoC-3, apolipoprotein CIII, Apo-CIII, IPR008403, apolipoprotein C-III
External IDs	OMIM: 107720; MGI: 88055; HomoloGene: 81615; GeneCards: APOC3; OMA:APOC3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	116,833,072 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	46,146,934 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; mucosa of ileum; ; duodenum; ; gonad; ; amniotic fluid; ; human kidney; ; epithelium of colon; ; metanephros; ; left uterine tube;
	Top expressed in
	left lobe of liver; ; duodenum; ; jejunum; ; migratory enteric neural crest cell; ; yolk sac; ; ileum; ; right kidney; ; proximal tubule; ; median eminence; ; intestinal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lipid binding; lipase inhibitor activity; enzyme regulator activity; high-density lipoprotein particle receptor binding; cholesterol binding; phospholipid binding;
Cellular component	chylomicron; very-low-density lipoprotein particle; spherical high-density lipoprotein particle; extracellular region; early endosome; extracellular exosome; intermediate-density lipoprotein particle; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	negative regulation of cholesterol import; G protein-coupled receptor signaling pathway; negative regulation of very-low-density lipoprotein particle remodeling; lipid transport; chylomicron remnant clearance; negative regulation of fatty acid biosynthetic process; regulation of Cdc42 protein signal transduction; lipid metabolism; negative regulation of high-density lipoprotein particle clearance; phospholipid efflux; negative regulation of low-density lipoprotein particle clearance; negative regulation of very-low-density lipoprotein particle clearance; retinoid metabolic process; negative regulation of receptor-mediated endocytosis; lipid catabolic process; cholesterol efflux; negative regulation of lipoprotein lipase activity; cholesterol homeostasis; very-low-density lipoprotein particle assembly; negative regulation of triglyceride catabolic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; reverse cholesterol transport; triglyceride homeostasis; triglyceride metabolic process; triglyceride catabolic process; chylomicron remodeling; high-density lipoprotein particle remodeling; chylomicron assembly; lipoprotein metabolic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	345
	11814
	ENSG00000110245
	ENSMUSG00000032081
	P02656
	P33622
	NM_000040
	NM_023114; NM_001289755; NM_001289756; NM_001289833
	NP_000031
	NP_001276684; NP_001276685; NP_001276762; NP_075603
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is secreted by the liver as well as the small intestine, and is found on triglyceride-rich lipoproteins such as chylomicrons, very low density lipoprotein (VLDL), and remnant cholesterol.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110245 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032081 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, Lund-Katz S, Phillips MC, Tall AR, Kathiresan S, DaSilva-Jardine P, Yates NA, Rader D (2017). "A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels". Nature Medicine. 23 (9): 1086–1094. doi:10.1038/nm.4390. PMC 5669375. PMID 28825717.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110245 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032081 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid28825717-5] Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci N, Zavadoski WJ, Sun Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, Lund-Katz S, Phillips MC, Tall AR, Kathiresan S, DaSilva-Jardine P, Yates NA, Rader D (2017). "A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels". Nature Medicine. 23 (9): 1086–1094. doi:10.1038/nm.4390. PMC 5669375. PMID 28825717.

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