Arsenic trioxide
| Identifiers | |
|---|---|
CAS Number
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| ECHA InfoCard | 100.014.075 |
CompTox Dashboard (EPA)
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| Properties | |
Chemical formula
|
As4O6 |
| Molar mass | 395.680 g·mol−1 |
| Appearance | white solid |
| Density | 3.74 g/cm3 |
| Melting point | 312.2 °C (594.0 °F; 585.3 K) |
| Boiling point | 465 °C (869 °F; 738 K) |
Solubility in water
|
20 g/L (25 °C) (see text) |
| Hazards | |
| GHS labelling: | |
Pictograms
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|
Signal word
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Danger |
Hazard statements
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H300, H314, H350, H410 |
Precautionary statements
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P201, P202, P260, P264, P270, P273, P280, P301+P330+P331, P303+P361+P353, P304+P340+P310, P305+P351+P338+P310, P308+P313, P363, P391, P405, P501 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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Arsenic trioxide is the inorganic compound with the formula As4O6.[1] As an industrial chemical, its major uses include the manufacture of wood preservatives, pesticides, and glass. For medical purposes, it is sold under the brand name Trisenox among others[2][3] when used as a medication to treat a type of cancer known as acute promyelocytic leukemia.[4] For this use it is given by injection into a vein.[4]
Arsenic trioxide was approved for medical use in the United States in 2000.[4] It is on the World Health Organization's List of Essential Medicines.[5] Approximately 50,000 tonnes were produced in 1991.[6] Due to its toxicity, a number of countries have regulations around its manufacture and sale.[7]
- ^ Sun H (2010). Biological Chemistry of Arsenic, Antimony and Bismuth. John Wiley & Sons. p. 295. ISBN 9780470976227. Archived from the original on 14 April 2023. Retrieved 18 March 2023.
- ^ "Trisenox- arsenic trioxide injection, solution". DailyMed. 30 June 2022. Archived from the original on 3 February 2024. Retrieved 3 February 2024.
- ^ "Trisenox EPAR". European Medicines Agency. 10 August 2010. Archived from the original on 16 August 2023. Retrieved 3 February 2024.
- ^ a b c "Arsenic Trioxide Monograph for Professionals". Drugs.com. Archived from the original on 15 November 2019. Retrieved 15 November 2019.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ Grund SC, Hanusch K, Wolf HU. "Arsenic and Arsenic Compounds". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a03_113.pub2. ISBN 978-3-527-30673-2.
- ^ Consolidated List of Products Whose Consumption And/or Sale Have Been Banned, Withdrawn, Severely Restricted Or Not Approved by Governments: Chemicals (PDF). United Nations Publications. 2009. p. 24. ISBN 9789211302196.