B-cell maturation antigen

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

BCMA TALL-1 binding domain
BCMA TALL-1 binding domain
	crystal structure of stall-1 and bcma
Identifiers
Symbol	BCMA-Tall_bind
Pfam	PF09257
InterPro	IPR015337
SCOP2	1oqd / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

TNFRSF17
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OQD, 1XU2, 2KN1, 4ZFO
Identifiers
Aliases	TNFRSF17, BCM, BCMA, CD269, TNFRSF13A, tumor necrosis factor receptor superfamily member 17, TNF receptor superfamily member 17
External IDs	OMIM: 109545; MGI: 1343050; HomoloGene: 920; GeneCards: TNFRSF17; OMA:TNFRSF17 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	11,968,068 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	11,137,938 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of transverse colon; ; jejunal mucosa; ; mucosa of sigmoid colon; ; testicle; ; lymph node; ; epithelium of nasopharynx; ; appendix; ; spleen; ; duodenum;
	Top expressed in
	blastocyst; ; morula; ; duodenum; ; jejunum; ; spleen; ; lip; ; thymus; ; secondary oocyte; ; colon; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity;
Cellular component	endomembrane system; plasma membrane; membrane; integral component of membrane;
Biological process	multicellular organism development; tumor necrosis factor-mediated signaling pathway; lymphocyte homeostasis; cell population proliferation; immune system process; adaptive immune response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	608
	21935
	ENSG00000048462
	ENSMUSG00000022496
	Q02223
	O88472
	NM_001192
	NM_011608
	NP_001183
	NP_035738
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.

TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).^[5]^[6]^[7]

Serum B-cell maturation antigen (sBCMA) is the cleaved form of BCMA, found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM).^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000048462 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022496 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Laâbi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A (November 1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma". The EMBO Journal. 11 (11): 3897–3904. doi:10.1002/j.1460-2075.1992.tb05482.x. PMC 556899. PMID 1396583.
^ Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (April 1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed". Nucleic Acids Research. 22 (7): 1147–1154. doi:10.1093/nar/22.7.1147. PMC 523635. PMID 8165126.
^ "Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17".
^ Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, et al. (January 2020). "Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies". The Journal of Allergy and Clinical Immunology. In Practice. 8 (1): 283–291.e1. doi:10.1016/j.jaip.2019.08.012. PMC 6980522. PMID 31430592.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000048462 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022496 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1396583-5] Laâbi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A (November 1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma". The EMBO Journal. 11 (11): 3897–3904. doi:10.1002/j.1460-2075.1992.tb05482.x. PMC 556899. PMID 1396583.

[pmid8165126-6] Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (April 1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed". Nucleic Acids Research. 22 (7): 1147–1154. doi:10.1093/nar/22.7.1147. PMC 523635. PMID 8165126.

[entrez-7] "Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17".

[8] Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, et al. (January 2020). "Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies". The Journal of Allergy and Clinical Immunology. In Practice. 8 (1): 283–291.e1. doi:10.1016/j.jaip.2019.08.012. PMC 6980522. PMID 31430592.

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