Basigin

BSG
Available structures
PDB	Ortholog search: A0A087X2B5 PDBe A0A087X2B5 RCSB
List of PDB id codes
	4U0Q, 3B5H, 3I84, 3I85, 3QQN, 3QR2
Identifiers
Aliases	BSG, 5F7, CD147, EMMPRIN, M6, OK, TCSF, basigin (Ok blood group), EMPRIN, SLC7A11, HAb18G
External IDs	OMIM: 109480; MGI: 88208; HomoloGene: 1308; GeneCards: BSG; OMA:BSG - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	583,494 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,547,803 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right testis; ; left testis; ; mucosa of transverse colon; ; right auricle of heart; ; left ventricle; ; right frontal lobe; ; stromal cell of endometrium; ; right adrenal cortex; ; left adrenal gland;
	Top expressed in
	choroid plexus of fourth ventricle; ; molar; ; interventricular septum; ; myocardium of ventricle; ; left lung lobe; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; tail of embryo; ; spermatocyte; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; mannose binding; carbohydrate binding; monocarboxylic acid transmembrane transporter activity; cadherin binding; cell-cell adhesion mediator activity;
Cellular component	integral component of membrane; membrane; focal adhesion; melanosome; Golgi membrane; plasma membrane; integral component of plasma membrane; acrosomal membrane; mitochondrion; membrane raft; sarcolemma; extracellular exosome; intracellular membrane-bounded organelle; axon;
Biological process	response to peptide hormone; extracellular matrix disassembly; extracellular matrix organization; odontogenesis of dentin-containing tooth; cell surface receptor signaling pathway; decidualization; pyruvate metabolic process; response to mercury ion; response to cAMP; embryo implantation; leukocyte migration; monocarboxylic acid transport; protein localization to plasma membrane; homophilic cell adhesion via plasma membrane adhesion molecules; axon guidance; dendrite self-avoidance;
	Sources:Amigo / QuickGO
Orthologs
	682
	12215
	ENSG00000172270
	ENSMUSG00000023175
	P35613
	P18572
	NM_001728; NM_198589; NM_198590; NM_198591; NM_001322243
	NM_001077184; NM_009768
	NP_001309172; NP_001719; NP_940991; NP_940992; NP_940993
	NP_001070652; NP_033898
	Wikidata
View/Edit Human	View/Edit Mouse

Basigin (BSG) also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the BSG gene.^[5]^[6]^[7] This protein is a determinant for the Ok blood group system. There are three known antigens in the Ok system; the most common being Ok^a (also called OK1), OK2 and OK3. Basigin has been shown to be an essential receptor on red blood cells for the human malaria parasite, Plasmodium falciparum.^[8] The common isoform of basigin (basigin-2) has two immunoglobulin domains, and the extended form basigin-1 has three.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172270 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023175 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kasinrerk W, Fiebiger E, Stefanová I, Baumruker T, Knapp W, Stockinger H (August 1992). "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule". Journal of Immunology. 149 (3): 847–854. doi:10.4049/jimmunol.149.3.847. PMID 1634773. S2CID 24602674.
^ Yurchenko V, Constant S, Bukrinsky M (March 2006). "Dealing with the family: CD147 interactions with cyclophilins". Immunology. 117 (3): 301–309. doi:10.1111/j.1365-2567.2005.02316.x. PMC 1782239. PMID 16476049.
^ Miyauchi T, Masuzawa Y, Muramatsu T (November 1991). "The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen". Journal of Biochemistry. 110 (5): 770–774. doi:10.1093/oxfordjournals.jbchem.a123657. PMID 1783610.
^ Cite error: The named reference pmid22080952 was invoked but never defined (see the help page).
^ Muramatsu T (May 2016). "Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners". Journal of Biochemistry. 159 (5): 481–490. doi:10.1093/jb/mvv127. PMC 4846773. PMID 26684586.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172270 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023175 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Kasinrerk W, Fiebiger E, Stefanová I, Baumruker T, Knapp W, Stockinger H (August 1992). "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule". Journal of Immunology. 149 (3): 847–854. doi:10.4049/jimmunol.149.3.847. PMID 1634773. S2CID 24602674.

[yurch-6] Yurchenko V, Constant S, Bukrinsky M (March 2006). "Dealing with the family: CD147 interactions with cyclophilins". Immunology. 117 (3): 301–309. doi:10.1111/j.1365-2567.2005.02316.x. PMC 1782239. PMID 16476049.

[Miyauchi_1992-7] Miyauchi T, Masuzawa Y, Muramatsu T (November 1991). "The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen". Journal of Biochemistry. 110 (5): 770–774. doi:10.1093/oxfordjournals.jbchem.a123657. PMID 1783610.

[pmid22080952-8] Cite error: The named reference pmid22080952 was invoked but never defined (see the help page).

[oup-9] Muramatsu T (May 2016). "Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners". Journal of Biochemistry. 159 (5): 481–490. doi:10.1093/jb/mvv127. PMC 4846773. PMID 26684586.

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