Bumetanide

Bumetanide
Clinical data
Trade namesBumex, Burinex, others
AHFS/Drugs.comMonograph
MedlinePlusa684051
License data
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth, intravenous, intramuscular
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
BioavailabilityAlmost complete (~80%)
Protein binding97%
MetabolismLiver
Elimination half-life~0.8 hours
ExcretionKidney
Identifiers
IUPAC name
  • 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.044.534
Chemical and physical data
FormulaC17H20N2O5S
Molar mass364.42 g·mol−1
3D model (JSmol)
SMILES
  • c1ccccc1Oc2c(NCCCC)cc(C(=O)O)cc2S(=O)(=O)N
InChI
  • InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23) Y
  • Key:MAEIEVLCKWDQJH-UHFFFAOYSA-N Y
  (verify)

Bumetanide, sold under the brand name Bumex among others, is a medication used to treat swelling and high blood pressure.[1] This includes swelling as a result of heart failure, liver failure, or kidney problems.[1] It may work for swelling when other medications have not.[1] For high blood pressure it is not a preferred treatment.[1] It is taken by mouth, or by injection into a vein or muscle.[1] Effects generally begin within an hour and last for about six hours.[1]

Common side effects include dizziness, low blood pressure, low blood potassium, muscle cramps, and kidney problems.[1] Other serious side effects may include hearing loss and low blood platelets.[1] Blood tests are recommended regularly for those on treatment.[1] Safety during pregnancy and breastfeeding is unclear.[2] Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys.[3][1]

Bumetanide was patented in 1968 and came into medical use in 1972.[4] It is on the World Health Organization's List of Essential Medicines.[5] It is available as a generic medication.[3] In 2020, it was the 270th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[6][7]

  1. ^ a b c d e f g h i j "Bumetanide Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 8 April 2019.
  2. ^ "Bumetanide (Bumex) Use During Pregnancy". Drugs.com. Retrieved 8 April 2019.
  3. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 225–226. ISBN 978-0-85711-338-2.
  4. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 458. ISBN 978-3-527-60749-5.
  5. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  6. ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  7. ^ "Bumetanide - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
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