CCR2

CCR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KAD, 1KP1
Identifiers
Aliases	CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C motif chemokine receptor 2
External IDs	OMIM: 601267; MGI: 106185; HomoloGene: 537; GeneCards: CCR2; OMA:CCR2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,360,940 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,913,594 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; bone marrow cell; ; appendix; ; spleen; ; lymph node; ; trabecular bone; ; parietal pleura; ; rectum;
	Top expressed in
	lumbar spinal ganglion; ; blood; ; tibiofemoral joint; ; granulocyte; ; ankle; ; intercostal muscle; ; body of femur; ; bone marrow; ; ankle joint; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	CCR2 chemokine receptor binding; G protein-coupled receptor activity; protein homodimerization activity; signal transducer activity; chemokine receptor activity; C-C chemokine receptor activity; protein binding; cytokine binding; chemokine (C-C motif) ligand 2 binding; chemokine (C-C motif) ligand 12 binding; chemokine (C-C motif) ligand 7 binding; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; perikaryon; membrane; plasma membrane; integral component of plasma membrane; soma; dendrite; perinuclear region of cytoplasm; cytoplasm; cytosol; external side of plasma membrane;
Biological process	negative regulation of adenylate cyclase activity; receptor signaling pathway via JAK-STAT; chemokine-mediated signaling pathway; cellular calcium ion homeostasis; positive regulation of monocyte chemotaxis; dendritic cell chemotaxis; chemotaxis; blood vessel remodeling; response to wounding; immune response; inflammatory response; viral process; positive regulation of astrocyte chemotaxis; signal transduction; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; monocyte chemotaxis; positive regulation of T-helper 1 type immune response; negative regulation of type 2 immune response; humoral immune response; cellular defense response; regulation of vascular endothelial growth factor production; positive regulation of T cell chemotaxis; negative regulation of angiogenesis; sensory perception of pain; cellular homeostasis; regulation of cell migration; positive regulation of interferon-gamma production; positive regulation of interleukin-2 production; T-helper 17 cell chemotaxis; negative regulation of eosinophil degranulation; positive regulation of alpha-beta T cell proliferation; homeostasis of number of cells within a tissue; positive regulation of inflammatory response; positive regulation of T cell activation; leukocyte adhesion to vascular endothelial cell; positive regulation of immune complex clearance by monocytes and macrophages; neutrophil clearance; positive regulation of leukocyte tethering or rolling; positive regulation of monocyte extravasation; positive regulation of CD8-positive, alpha-beta T cell extravasation; positive regulation of hematopoietic stem cell migration; cytokine-mediated signaling pathway; hemopoiesis; calcium-mediated signaling; cell chemotaxis; positive regulation of cold-induced thermogenesis; regulation of T cell cytokine production; monocyte extravasation; regulation of T cell differentiation; regulation of inflammatory response; positive regulation of synaptic transmission, glutamatergic; inflammatory response to wounding; macrophage migration; positive regulation of thymocyte migration; positive regulation of NMDA glutamate receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	729230
	12772
	ENSG00000121807
	ENSMUSG00000049103
	P41597
	P51683
	NM_001123041; NM_001123396
	NM_009915
	NP_001116513; NP_001116868; NP_001116868.1
	NP_034045
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene.^[5] CCR2 is a CC chemokine receptor.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121807 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049103 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121807 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049103 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

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