CYP1A1

CYP1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4I8V
Identifiers
Aliases	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX, CYPIA1, cytochrome P450 family 1 subfamily A member 1
External IDs	OMIM: 108330; MGI: 88588; HomoloGene: 68062; GeneCards: CYP1A1; OMA:CYP1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,725,536 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,611,107 bp
RNA expression pattern
	Top expressed in
	testicle; ; jejunal mucosa; ; islet of Langerhans; ; trachea; ; right lobe of liver; ; epithelium of colon; ; urinary bladder; ; cartilage tissue; ; skin of leg; ; mucosa of urinary bladder;
	Top expressed in
	transitional epithelium of urinary bladder; ; lip; ; olfactory epithelium; ; gastrula; ; right lung; ; embryo; ; embryo; ; skin of external ear; ; jejunum; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; flavonoid 3'-monooxygenase activity; demethylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; metal ion binding; steroid hydroxylase activity; catalytic activity; protein binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; enzyme binding; vitamin D 24-hydroxylase activity; oxidoreductase activity; aromatase activity; oxidoreductase activity, acting on diphenols and related substances as donors; monooxygenase activity; estrogen 16-alpha-hydroxylase activity; Hsp70 protein binding; Hsp90 protein binding;
Cellular component	cytoplasm; organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; endoplasmic reticulum; mitochondrion; mitochondrial inner membrane;
Biological process	response to immobilization stress; maternal process involved in parturition; response to hypoxia; 9-cis-retinoic acid biosynthetic process; response to organic cyclic compound; coumarin metabolic process; vitamin D metabolic process; insecticide metabolic process; response to hyperoxia; response to antibiotic; demethylation; cellular response to organic cyclic compound; response to virus; ageing; hepatocyte differentiation; epoxygenase P450 pathway; dibenzo-p-dioxin catabolic process; response to arsenic-containing substance; response to organic substance; positive regulation of G1/S transition of mitotic cell cycle; response to vitamin A; response to lipopolysaccharide; omega-hydroxylase P450 pathway; response to wounding; dibenzo-p-dioxin metabolic process; response to nematode; response to iron(III) ion; flavonoid metabolic process; response to food; liver development; camera-type eye development; digestive tract development; cell population proliferation; response to herbicide; porphyrin-containing compound metabolic process; ethylene metabolic process; lipid hydroxylation; steroid metabolic process; cellular response to copper ion; amine metabolic process; toxin metabolic process; response to toxic substance; regulation of lipid metabolic process; heterocycle metabolic process; hydrogen peroxide biosynthetic process; developmental process; long-chain fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1543
	13076
	ENSG00000140465
	ENSMUSG00000032315
	P04798
	P00184
	NM_000499; NM_001319216; NM_001319217
	NM_001136059; NM_009992
	NP_000490; NP_001306145; NP_001306146
	NP_001129531; NP_034122
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein^[5] that in humans is encoded by the CYP1A1 gene.^[6] The protein is a member of the cytochrome P450 superfamily of enzymes.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140465 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032315 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawajiri K (1999). "CYP1A1". IARC Scientific Publications (148): 159–172. PMID 10493257.
^ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
^ Smith G, Stubbins MJ, Harries LW, Wolf CR (Dec 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 28 (12): 1129–1165. doi:10.1080/004982598238868. PMID 9890157.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140465 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032315 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Kawajiri_1999-5] Kawajiri K (1999). "CYP1A1". IARC Scientific Publications (148): 159–172. PMID 10493257.

[Nelson_2004-6] Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

[Smith_1998-7] Smith G, Stubbins MJ, Harries LW, Wolf CR (Dec 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 28 (12): 1129–1165. doi:10.1080/004982598238868. PMID 9890157.

[1]

[2]

[3]

[4]

[5]

[6]

[7]