CYP1A2

CYP1A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HI4
Identifiers
Aliases	CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2, CYPIA2
External IDs	OMIM: 124060; MGI: 88589; HomoloGene: 68082; GeneCards: CYP1A2; OMA:CYP1A2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,756,607 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,590,986 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; right lobe of liver; ; superficial temporal artery; ; cardia; ; nipple; ; vena cava; ; mucosa of paranasal sinus; ; subthalamic nucleus; ; sperm; ; ventral tegmental area;
	Top expressed in
	left lobe of liver; ; olfactory epithelium; ; gallbladder; ; sexually immature organism; ; duodenum; ; thoracic diaphragm; ; medial head of gastrocnemius muscle; ; right lung lobe; ; thymus; ; pancreas;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; demethylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; metal ion binding; caffeine oxidase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; enzyme binding; oxidoreductase activity; aromatase activity; electron transfer activity; monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; endoplasmic reticulum;
Biological process	response to immobilization stress; toxin metabolic process; steroid metabolic process; response to estradiol; alkaloid metabolic process; response to organic cyclic compound; lung development; lipid metabolism; epoxygenase P450 pathway; cellular response to cadmium ion; post-embryonic development; monocarboxylic acid metabolic process; response to organic substance; oxidative demethylation; response to lipopolysaccharide; methylation; steroid catabolic process; omega-hydroxylase P450 pathway; dibenzo-p-dioxin metabolic process; heterocycle metabolic process; cellular respiration; cellular aromatic compound metabolic process; regulation of gene expression; hydrogen peroxide biosynthetic process; monoterpenoid metabolic process; xenobiotic metabolic process; porphyrin-containing compound metabolic process; toxin biosynthetic process; cellular response to copper ion; electron transport chain; long-chain fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1544
	13077
	ENSG00000140505
	ENSMUSG00000032310
	P05177
	P00186
	NM_000761
	NM_009993
	NP_000752
	NP_034123
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body.^[5] In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140505 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032310 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (January 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046. S2CID 18448751.
^ Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1987). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15". Journal of Experimental Pathology. 3 (1): 1–17. PMID 3681487.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140505 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032310 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15128046-5] Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (January 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046. S2CID 18448751.

[pmid3681487-6] Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1987). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15". Journal of Experimental Pathology. 3 (1): 1–17. PMID 3681487.

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