CYP2A6

CYP2A6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RUI, 1Z10, 1Z11, 2FDU, 2FDV, 2FDW, 2FDY, 3EBS, 3T3Q, 3T3R, 4EJJ
Identifiers
Aliases	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB, cytochrome P450 family 2 subfamily A member 6
External IDs	OMIM: 122720; MGI: 88597; HomoloGene: 85917; GeneCards: CYP2A6; OMA:CYP2A6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	40,850,447 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	26,542,973 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; paraflocculus of cerebellum; ; middle frontal gyrus; ; frontal pole; ; Brodmann area 10; ; nasal epithelium; ; cerebellar vermis; ; male germ cell; ; sperm; ; thalamus;
	Top expressed in
	proximal tubule; ; human kidney; ; right kidney; ; hepatobiliary system; ; liver; ; esophagus; ; respiratory epithelium; ; thymus; ; nasal epithelium; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; arachidonic acid epoxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; enzyme binding; oxidoreductase activity; coumarin 7-hydroxylase activity; steroid hydroxylase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; cytoplasmic microtubule; cytoplasm;
Biological process	steroid metabolic process; epoxygenase P450 pathway; coumarin catabolic process; coumarin metabolic process; organic acid metabolic process; xenobiotic metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1548
	13087
	ENSG00000255974
	ENSMUSG00000005547
	P11509
	P20852
	NM_000762
	NM_007812
	NP_000753
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

The CYP2A6 gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000255974 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005547 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ This article incorporates public domain material from "Entrez Gene: CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6". Reference Sequence collection. National Center for Biotechnology Information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000255974 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005547 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] This article incorporates public domain material from "Entrez Gene: CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6". Reference Sequence collection. National Center for Biotechnology Information.

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